Sr. Associate Scientist I-II, Antibody Discovery and Optimization

Mosaic Biosciences•Boulder, CO

6d•$75,000 - $95,000•Onsite

About The Position

The Sr. Associate Scientist will join the Antibody Discovery and Optimization team in Boulder, Colorado. The role focuses on independently constructing, validating, and screening surface-displayed antibody libraries, and contributing to client programs by delivering complete and accurate data packages on schedule. The successful candidate will have hands-on display technology experience, including yeast display and preferably phage display, as well as DNA library construction and FACS experience. Depending on experience and demonstrated capability, the scientist will take on increasingly complex protocol development, problem-solving, and client-facing scientific discussions. The position is full-time and requires in-person work in the company’s Boulder laboratories. Candidates may be considered at the Sr. Associate Scientist I or II level based on education and relevant industry experience. Base salary ranges are $75,000–$85,000 for level I and $85,000–$95,000 for level II. Benefits include health and dental insurance, disability and life insurance, a 401(k) with company match, and bonus opportunities based on company success.

Requirements

BS or MS in molecular biology, biochemistry, or a related scientific discipline.
For Sr. Associate Scientist I: BS degree with at least 4 years of industry experience, or MS degree with at least 2 years of industry experience.
For Sr. Associate Scientist II: BS degree with at least 6 years of industry experience, or MS degree with at least 4 years of industry experience.
Direct, hands-on experience with yeast display systems.
Experience with molecular biology techniques, including RT-PCR, PCR, overlap extension PCR, cloning, primer design, and in-silico DNA construct design.
Experience with flow cytometry.
Experience in cloning, expression, and antibodies/libraries in bacterial and yeast cells.
Ability to work independently with minimal guidance, apply sound scientific and analytical problem-solving, and troubleshoot moderately complex issues.
Strong written and verbal communication skills, with the ability to share progress, risks, and experimental deviations promptly.
Willingness to learn and adopt new techniques.

Nice To Haves

Phage display experience.

Responsibilities

Execute antibody discovery and affinity maturation campaigns using yeast and phage display, working independently once general assignments are made.
Construct libraries using PCR, RT-PCR, Golden Gate/Gibson assembly, and mutagenesis in phage and yeast display vectors.
Conduct high-throughput screening of antibody display campaign outputs using flow cytometry.
Develop and refine protocols, troubleshoot routine and complex experimental issues, and suggest improvements or variations to established methods.
Analyze and interpret experimental data and clearly communicate findings to the team and project leads, including through internal presentations.
Identify technical risks early and propose mitigation strategies to protect project scope and timelines.
Work on multiple projects simultaneously, ensuring timely delivery of potential therapeutic leads, with work reviewed at key checkpoints.
Build productive relationships within the immediate team and work cross-functionally with Project Leads and Commercial teams to ensure data packages are complete, accurate, and delivered on schedule.
Document data in an electronic lab notebook (ELN) and LIMS in an organized, reproducible manner.
Contribute ideas and participate actively in group problem-solving to address challenging targets.