Sr Scientist, Analytical and Biological Mass Spectrometry (ABMS)

Regeneron Pharmaceuticals • Tarrytown, GA

9d • $109,900 - $179,300 • Onsite

About The Position

Regeneron is seeking a highly motivated Sr. Scientist to join its Analytical and Biological Mass Spectrometry (ABMS) Group. The role is based in an innovative liquid chromatography and mass spectrometry laboratory and involves developing and performing top-down and bottom-up mass spectrometry with state-of-the-art LC-MS instruments to characterize therapeutic drugs. The scientist will focus on biochemical characterization of therapeutic proteins throughout drug development and develop and implement LC/MS-based methods for elucidating protein primary structure and related attributes, including peptide mapping, disulfide linkage determination, carbohydrate profiling, post-translational modifications, sequence variant analysis, charge and size variant characterization, and host-cell protein analysis.

The role supports development of monoclonal antibody-based therapeutic proteins, bispecific antibodies, Fc-fusion proteins, antibody conjugates, and other modalities, including adeno-associated virus, mRNA, and siRNA. It also involves LC-MS bioanalytical strategies and high-throughput methods to quantify biomarkers and diverse drug candidates in biological matrices for preclinical and early-stage clinical pharmacokinetic studies. The scientist will explore emerging analytical and bioanalysis technologies, collaborate with therapeutic function areas to support drug discovery, and contribute to a team-oriented, science-driven organization.

Requirements

• Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 0–5 years of postdoctoral experience; or an MS degree with 5+ years of experience; or a BS degree with 7+ years of relevant experience.
• Experience in liquid chromatography and mass spectrometry, with a proven track record of developing MS, LC-MS, or LC-MS/MS methods.
• Familiarity with sophisticated liquid chromatography and mass spectrometry technologies and relevant data-analysis software.
• Strong organizational, communication, and interpersonal skills.
• Ability to learn new technologies quickly and apply good problem-solving skills.
• Enthusiasm for science and motivation to contribute in a team environment.

Responsibilities

• Develop primarily LC/MS-based analytical methods to support development of therapeutic proteins and other modalities.
• Conduct analytical experiments and analyze LC-MS data to elucidate quality attributes of therapeutic protein candidates, drug products, and critical reagents.
• Develop LC-MS-based bioanalytical strategies and high-throughput methods for quantifying biomarkers and drug candidates in biological matrices to support preclinical and early-stage clinical PK studies.
• Explore novel analytical and bioanalysis technologies and emerging platforms to meet evolving portfolio needs.
• Collaborate with therapeutic function areas to support drug discovery.

Benefits

• Annual bonuses or other incentive plans may be included.
• Equity awards may be included.
• Pension or retirement benefits may be included.
• 401(k) company match may be included.
• Health and wellness programs may be included.
• Fitness centers may be available.
• Insurance benefits may include medical, dental, vision, life, and disability coverage.
• Paid time off may be included.
• Family support benefits may be included.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior