SPR Senior Scientist in Protein Technologies Center

St. Jude Children's Research Hospital•Memphis, TN

21h•Onsite

About The Position

The Protein Technologies Center (PTC) is a team of 13 scientists within the Department of Structural Biology, specializing in protein biochemistry, molecular biology, biophysics, and structural biology. This center collaborates with researchers at St. Jude to understand the molecular basis of biological specificity and complexity. We are seeking an experienced Biophysicist/Surface Plasmon Resonance (SPR) Senior Scientist to characterize molecular interactions using SPR and other methods to support structural biology and ligand discovery initiatives. At St. Jude Children’s Research Hospital, we provide world-class facilities, state-of-the-art technologies, extraordinary support, and a collaborative environment where science translates into survival for children. This is a hands-on laboratory role for an individual who enjoys assay design and execution, and close collaboration with scientists and investigators. The selected candidate will be responsible for the operation and maintenance of SPR instruments and must be capable of independently planning, optimizing, and executing experiments to measure kinetic and equilibrium binding constants. Additionally, the individual will explore, develop, and apply novel methods and technologies to advance the understanding of protein-ligand interactions, oligomerization, stoichiometry, and stability.

Requirements

Proficient, hands-on experience with Biacore instruments (T200, S200, 8K, or 1K) and/or other systems such as Carterra LSA, Bruker, Nicoya, or Sartorius SF3 for analyzing diverse molecular interactions.
A good understanding of macromolecular structure, protein-ligand interactions, and biophysical characteristics.
A proven ability to manage multiple projects concurrently.
Bachelor's degree in relevant scientific area is required.
Ten (10) years relevant work experience is required with a Bachelor's degree.
Eight (8) years of relevant work experience is required with a Master's degree.
Five (5) years of relevant work experience is required with a PhD.

Responsibilities

Independently design, execute, and analyze high- to medium-throughput biosensor-based molecular interaction assays utilizing SPR instruments.
Oversee daily operations, maintenance, and scheduling for all biophysical instruments within the center.
Engage in the preparation of manuscripts and the presentation of findings in various professional forums.