Senior Associate Scientist II, Protein Sciences

Solid Biosciences•Boston, MA

9h•Onsite

About The Position

Solid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich’s ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. We are advancing a diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid’s mission is to improve the daily lives of patients living with devastating rare diseases. We are seeking a skilled and motivated associate scientist to join the Molecular Therapeutics team to purify AAV libraries and to define the mechanism of transduction of selected capsids. The ideal candidate will have a strong background in protein science including protein binding assays, protein structure, and cell biology. This role will be based in Solid’s Corporate Headquarters located in Hood Park in Charlestown, MA and is a primarily onsite position.

Requirements

Bachelor of Science with 3-5 years of industry experience, or MS with 0-3+ years of experience in protein science research
Experience with AAV and/or antibody production and drug development
Strong technical skills in protein biochemistry and cell biology to define the mechanism of AAV transduction
Proficiency in computing include Geneious, BLAST, Ensembl, NCBI, Uniprot, USCS, GTEx, Microsoft, PRISM statistics program
Strong problem-solving skills and the ability to work independently and collaboratively.
Excellent communication and presentation skills.

Responsibilities

Optimize methods for production and isolation of AAV capsid libraries using automated liquid handlers such as Tecan
In vitro AAV transduction experiments in normal and CRISPr KO cells
Protein binding and inhibition experiments
Contribute to modelling of protein structures
Collaborate within the molecular therapeutics team and across the R&D organization including computational biologists, analytical development, and process development
Communicate findings and insights to stakeholders through reports, presentations, and visualizations.

Benefits

Competitive Health and Dental programs with flexible plan offerings, including FSA and HSA programs
401(k) program participation with competitive company matched contributions
Eligibility to participate in Solid’s Employee Stock Purchase Plan
Mobile phone subsidy for eligible employees
Tuition Reimbursement
Vision Coverage
Life Insurance
Voluntary Pet Insurance
Employee Discount Program on Travel, Entertainment, and Services
Employee Assistance Programs
Daily Subsidized Lunch Delivery (onsite @ Hood Park)
Free Onsite Full-Service Gym (onsite @ Hood Park)
Employee Parking (onsite @ Hood Park)
12 Observed Holidays and a winter shut down
15-day PTO Policy and a 40-hour rollover YoY
40-hour Sick Policy
8 Hour Floating Holiday