Sr Technical Product Owner

Twist Bioscience•South San Francisco, CA
•$160,000 - $191,000•Hybrid

About The Position

Twist Bioscience is seeking a Senior Technical Product Owner to lead cross-functional system initiatives supporting its synthetic DNA platform and commercial, scientific, and operational teams. The role is the primary business-facing partner for system projects, responsible for defining functional requirements and working closely with engineering and project management, who own technical design, delivery sequencing, and timelines. It combines hands-on requirements gathering, documentation, and testing with cross-functional relationship management and coordination across product, engineering, and business teams. The role translates complex business and product needs into executable technical requirements, ensures solutions align with business strategies and objectives, and helps improve project intake, documentation, and testing practices. It includes requirements and solution definition, delivery partnership and communication, end-to-end user acceptance testing, launch and stabilization support, and continuous improvement. This position is hybrid in South San Francisco, California. The California-based base salary range is $160,000–$191,000, with eligibility for bonus, equity, and a benefits package.

Requirements

  • Bachelor's degree in a technical, engineering, or scientific field.
  • At least 5 years of experience in a related field.
  • At least 5 years of experience in technical product management, customer relationship management, or products, systems, or applications experience.
  • Ability to translate scientific, operational, or customer needs into functional specifications aligned with technical constraints and business goals.
  • Excellent communication and collaboration skills, with the ability to partner with business stakeholders and technical teams.
  • Growth mindset and drive to continuously improve systems and processes.
  • Customer-centric mindset and strong customer empathy.
  • Ability to work in a fast-paced, agile development environment.

Nice To Haves

  • Advanced degree (Master’s or PhD).
  • Experience in biotech, life sciences, or synthetic biology environments.
  • Hands-on experience with Salesforce (SFDC), such as Sales Cloud, Service Cloud, or related integrations.
  • Experience with Laboratory Information Management Systems (LIMS), including sample tracking, workflow configuration, or integration with lab and enterprise systems.

Responsibilities

  • Lead requirements intake and clarification with stakeholders across Product, Marketing, Sales Operations, Finance, Customer Support, and R&D.
  • Define and document functional requirements, business rules, edge cases, constraints, exceptions, and acceptance criteria; account for impacted existing logic and translate requirements into development- and QA-ready epics and user stories.
  • Identify end-to-end impacted processes, systems, dependencies, subject matter experts, and stakeholders, including areas such as product setup, pricing, quoting, order intake, manufacturing, fulfillment, and invoicing.
  • Align with cross-system partners and subject matter experts to ensure requirements are complete and consistent across integrated systems and address emerging business needs.
  • Ensure requirements and solutions are compliant and audit-ready, including applicable SOX and ISO considerations, in partnership with Finance, Quality, and other stakeholders.
  • Advocate for customer needs throughout the product development process.
  • Provide development leads, architects, and project managers with end-to-end initiative context and scope, and lead functional grooming sessions.
  • Partner with project management, scrum masters, developers, architecture, and SWQA through design, build, testing, and delivery; clarify requirements and surface risks, gaps, and dependencies early.
  • Communicate scope, status, risks, and dependencies proactively and consistently to business stakeholders.
  • Influence scope tradeoffs and solution options by bringing business and cross-system context to technical discussions.
  • Plan and lead end-to-end user acceptance testing across multiple systems, including tester kickoff, providing context and demos, supporting issue logging and defect clarification, and obtaining stakeholder sign-off before go-live.
  • Support releases, hypercare, and post-launch stabilization by providing business context to assess issue criticality.
  • Stay informed about production issues and contribute business and system context to their resolution.
  • Recommend improvements to project execution, requirements gathering, and testing, including intake playbooks, documentation standards, and testing practices.
  • Identify opportunities to use AI tools to improve efficiency in requirements documentation, analysis, and testing.

Benefits

  • Eligible for a bonus.
  • Eligible for equity.
  • Generous benefits package.
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