Senior Scientist, Stem Cell-Derived Tissue Models( Contract)
About The Position
Join Amgen’s Mission of Serving Patients. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. In this vital role, you will join the Predictive Biology team to develop and validate biologically relevant models of human tissue using induced pluripotent stem cell (iPSC) or primary human tissue. A key focus will be validating tissue architecture, cellular composition, differentiation state, maturation, and functional relevance to ensure models are suitable for discovery and translational research.
Requirements
- PhD in a related discipline with 2+ years of experience
- MSc with 5+ years of experience.
- BSc with 8+ years of experience.
- PhD with 2+ years postdoctoral and/or industry experience in stem cell biology, developmental biology, tissue engineering, cell biology, bioengineering, molecular biology, organoid biology, or a related discipline.
- Hands-on experience culturing and differentiating stem cells across relevant model systems
- Experience validating tissue architecture using methods such as immunostaining, confocal microscopy, flow cytometry, high-content imaging, or functional assays.
- Experience optimizing media, growth factors, extracellular matrix conditions, differentiation timing, and co-culture conditions for multicellular model systems.
- Strong communication and collaboration skills and ability to work effectively as part of a multidisciplinary team.
Nice To Haves
- Familiarity with adult stem cell-derived organoids, Lgr5-positive stem cell biology, niche-factor-dependent epithelial systems, normal organoids, or patient-derived organoid platforms is preferred but not required.
- Demonstrated scientific productivity and technical credibility through peer-reviewed publications and patents
Responsibilities
- Develop human stem cell-derived models that represent tissue biology and enable disease-versus-normal comparisons.
- Differentiate stem cells into diverse tissue-relevant cell types.
- Build complex model systems, including organoids, assembloids, co-cultures, matrix-supported cultures, or other multicellular tissue-like systems.
- Optimize culture conditions, media composition, growth factor cues, extracellular matrix conditions, differentiation timing, and co-culture parameters.
- Validate model fidelity using readouts of cell identity, tissue architecture, maturation, and tissue-specific function.
- Document protocols, experimental designs, model validation data, and decision criteria in a clear and reproducible manner.
- Communicate results, limitations, and technical risks to cross-functional teams through written reports and oral presentations.
Benefits
- Competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
