Stem Cell Systems Technician

Becoming • San Francisco, CA

3d

About The Position

Becoming is building Developmental Intelligence: AI for predicting how organisms change over time. The company combines engineered metabolic environments, longitudinal measurement, and predictive models to make development understandable, testable, and controllable. It values speed, rigor, integrity, and ownership.

The Stem Cell Systems Technician will run and stabilize the biological systems at the core of the platform. This is an execution-focused role responsible for carrying out, standardizing, and scaling stem cell workflows into reliable systems. The technician will work closely with developmental biologists, engineers, and AI teams to ensure experiments are robust, reproducible, and integrated into closed-loop platforms.

The role includes maintaining and expanding human stem cell cultures, executing differentiation protocols, and performing cell culture operations such as passaging, feeding, media preparation, cryopreservation, and quality control. The technician will own SOPs and documentation, reduce variability and drift in long-running experiments, maintain structured experimental records and sample traceability, support sample collection for downstream assays, and assist with integrating biological systems into perfusion and closed-loop platforms. They will also help maintain lab readiness and manage reagents, consumables, and inventory.

Requirements

• Bachelor’s or Master’s degree in biology, bioengineering, or a related field.
• 1–4 years of hands-on stem cell culture experience.
• Strong fundamentals in aseptic technique and cell culture maintenance.
• Demonstrated experience writing or improving SOPs or structured protocols.
• High attention to detail and ability to execute repeatable, high-quality workflows.
• Comfort working in a fast-paced, evolving experimental environment.

Nice To Haves

• Experience with iPSCs or ESCs.

Responsibilities

• Maintain and expand human stem cell cultures, including iPSC, ESC, and derivatives.
• Execute differentiation protocols and support iterative optimization.
• Perform cell culture operations, including passaging, feeding, media preparation, cryopreservation, and quality control.
• Support co-culture and multi-cell-type systems as needed.
• Run long-horizon experiments requiring consistent execution over time.
• Write, maintain, and version-control standard operating procedures (SOPs).
• Translate experimental workflows into clear, reproducible protocols.
• Identify sources of variability and systematically reduce drift.
• Ensure consistent execution across time, operators, and conditions.
• Train team members on SOP-compliant workflows.
• Maintain structured, high-quality experimental records and logs.
• Ensure traceability between samples, conditions, and outcomes.
• Support sample collection for downstream assays, including omics, imaging, and histology.
• Assist with integrating biological systems into perfusion and closed-loop platforms.
• Work with engineering teams to ensure biological requirements are met in hardware systems.
• Maintain sterility, organization, and readiness of the lab environment.
• Manage reagents, consumables, and inventory for core workflows.

Benefits

• Competitive salary and meaningful equity.
• Full benefits.
• High-trust, high-ownership environment.
• Opportunity to define a new scientific category from the ground up.

What This Job Offers

• Job Type: Full-time