Senior Scientist, Pharmacokinetics
About The Position
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group seeks a strategic and collaborative Senior Scientist to support drug discovery and early clinical development. Based at the research laboratories in West Point, Pennsylvania, the role will characterize the drug metabolism and pharmacokinetic properties of peptides and protein therapeutics from discovery through early development, using advanced LC/MS techniques. A key focus is developing and implementing novel bioanalytical and automated workflows—including high-resolution mass spectrometry (HRMS) and proteomic approaches—to characterize new modalities. The Senior Scientist will independently design and execute LC-MS methods for therapeutic antibodies, peptides, and drug conjugates, and provide scientific leadership for automation-enabled discovery workflows. The role also applies state-of-the-art bioanalytical approaches to characterize large-molecule drug properties in vitro and collaborates with PDMB experts in Boston, South San Francisco, and West Point to develop efficient strategies for identifying and optimizing drug candidates.
Requirements
- Ph.D. with 0–3 years of relevant experience, or a Master's degree with at least 6 years of relevant experience, or a Bachelor's degree with at least 10 years of relevant experience, in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering, or a related field.
- Demonstrated method development and validation experience across various platforms, with deep LC/MS expertise for macrocyclic peptides, monoclonal antibodies, and drug conjugates.
- Strong hands-on experience with chromatographic separation and mass spectrometry methodologies for analysis of therapeutic proteins and peptides.
- Strong leadership, interpersonal, communication, and problem-solving skills, and the ability to collaborate and deliver high-quality results in a team-oriented, fast-paced environment.
- Commitment to a team-based approach to research and working synergistically and harmoniously with others.
- Required skills listed: ADME, cell-based assays, drug metabolism, electronic lab notebook (ELN), HRMS, in vitro research, monoclonal antibodies, peptides, and pharmacokinetics.
Nice To Haves
- Experience with in vitro and in vivo DMPK experimental design and analysis.
- Familiarity with electronic laboratory notebooks and related record-keeping approaches.
- Experience working within a research-driven pharmaceutical company.
- Strong publication track record.
Responsibilities
- Independently design and execute LC-MS methods to characterize therapeutic antibodies, peptides, and drug conjugates, including use of high-resolution mass spectrometers.
- Provide scientific leadership for automation-enabled discovery workflows and help define capabilities that improve throughput, reproducibility, and data generation across optimization platforms.
- Use state-of-the-art bioanalytical approaches to characterize large-molecule drug properties in in vitro matrices and support candidate selection.
- Collaborate with PDMB subject-matter experts in Boston, South San Francisco, and West Point to develop efficient strategies for identifying and optimizing drug candidates.
- Contribute to drug discovery and early clinical development efforts by characterizing DMPK properties of peptides and protein therapeutics.
Benefits
- Medical insurance and healthcare benefits for employees and family.
- Dental insurance.
- Vision insurance.
- Other insurance benefits.
- Retirement benefits, including a 401(k).
- Paid holidays.
- Vacation.
- Compassionate and sick days.
- Annual bonus eligibility.
- Long-term incentive eligibility, if applicable.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
