Senior Scientist, Pharmacokinetics
About The Position
The Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking a strategic-thinking and collaborative Senior Scientist to support drug discovery and early clinical development. Based at the research laboratories in West Point, Pennsylvania, the role focuses on using advanced LC/MS techniques to characterize the drug metabolism and pharmacokinetic properties of peptides and protein therapeutics from discovery through early development. A key focus is developing and implementing novel bioanalytical and automated workflows, including high-resolution mass spectrometry and proteomic approaches, to characterize new modalities. The Senior Scientist will independently design and execute LC-MS methods for therapeutic antibodies, peptides, and drug conjugates; provide scientific leadership for automation-enabled discovery workflows; and apply advanced bioanalytical approaches to characterize large-molecule drug properties in in vitro matrices. The role involves close collaboration with PDMB experts in Boston, South San Francisco, and West Point to develop efficient strategies for identifying and optimizing drug candidates. The successful candidate will innovate and execute independently while contributing effectively in a collaborative team environment.
Requirements
- Ph.D. with 0–3 years of relevant experience, Master's degree with at least 6 years of relevant experience, or Bachelor's degree with at least 10 years of relevant experience in biochemistry, chemistry, pharmacology, pharmaceutical sciences, biomedical engineering, or a related field.
- Demonstrated method development and validation experience across various platforms, with deep LC/MS expertise for macrocyclic peptides, monoclonal antibodies, and drug conjugates.
- Strong hands-on experience with chromatographic separation and mass spectrometry methodologies for analyzing therapeutic proteins and peptides.
- Strong leadership, interpersonal, communication, and problem-solving skills, with the ability to deliver high-quality results in a collaborative, team-oriented, fast-paced environment.
- Commitment to fostering a team-based research approach and working synergistically and harmoniously with others.
Nice To Haves
- Experience with DMPK in vitro and in vivo experimental design and analysis.
- Familiarity with electronic laboratory notebooks and related record-keeping approaches.
- Experience working within a research-driven pharmaceutical company.
- Strong publication track record.
Responsibilities
- Independently design and execute LC-MS methods to characterize therapeutic antibodies, peptides, and drug conjugates using LC-MS platforms, including high-resolution mass spectrometers.
- Provide scientific leadership for automation-enabled discovery workflows and help define future capabilities that increase throughput, reproducibility, and data generation across optimization platforms.
- Use state-of-the-art bioanalytical approaches to characterize large-molecule drug properties in various in vitro matrices to support candidate selection.
- Collaborate with PDMB subject-matter experts in Boston, South San Francisco, and West Point to build efficient strategies for identifying and optimizing drug candidates.
Benefits
- Medical, dental, vision, healthcare, and other insurance benefits for employees and their families.
- Retirement benefits, including a 401(k).
- Paid holidays, vacation, compassionate days, and sick days.
- Eligible for an annual bonus and long-term incentive, if applicable.
Stand Out From the Crowd
Upload your resume and get instant feedback on how well it matches this job.
What This Job Offers
Job Type
Full-time
Career Level
Senior
