Senior Scientist, In Vivo Pharmacology, Neuroscience
About The Position
The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept. In the role as a Senior Scientist within In Vivo Pharmacology, the ideal candidate performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing. They will perform and analyze pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology. The candidate will develop new assays and mouse models as needed, manage in vivo studies conducted at contract research organizations (CROs), and serve as an in vivo pharmacology representative or biology lead on program and platform teams, contributing to program strategy. They will also participate in the evaluations of external assets and technologies as needed.
Requirements
- Bachelor’s Degree and 7+ years of academic and / or industry experience
- Or Master’s Degree and 5+ years of academic and / or industry experience
- Or Ph.D. or equivalent advanced degree in the Life Sciences and 2+ of academic and / or industry experience
- Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
- Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
- Experience working with contract research organization (CROs)
- Strong organizational and communication skills
- Ability to work independently and as part of a team
- Detail-oriented with a commitment to scientific rigor and reproducibility
- Adaptability in a fast-paced, collaborative research environment
Nice To Haves
- PhD in Neuroscience or related field is required.
- Extensive expertise and practical experience in genetic medicines, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB), is required.
- Expertise and practical experience in one or more of the following areas: Neurodegenerative disease, such as Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease, particularly with respect to animal modeling; Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling; RNA biology and splice modulation
- Experience with rodent stereotaxic surgery
- Familiarity with in vivo bioluminescence imaging
- Familiarity with transcriptomics and/or proteomics
Responsibilities
- Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
- Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology
- Develops new assays and mouse models as needed
- Manages in vivo studies conducted at contract research organizations (CROs)
- Serves as an in vivo pharmacology representative or biology lead on program and platform teams, and as such, contributes to program strategy
- Participates in the evaluations of external assets and technologies as needed
Benefits
- wellbeing support
- retirement and financial protection benefits
- insurance offerings (medical, dental, vision, life and disability)
- Flexible Time Off (FTO)
- 11 paid company holidays each year
- 160 hours of paid vacation annually for new hires
- 3 optional holidays
- paid sick leave
- up to two paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
- annual Global Shutdown between Christmas Day and New Year's Day
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
