Scientist, In Vivo Pharmacology, Neuroscience
About The Position
At Bristol Myers Squibb, our employees often ask, “Who are you working for?”—a question that fuels collaboration, accountability, and urgency in our work. Our purpose-driven culture inspires us to discover, develop, and deliver innovative medicines to prevail over serious diseases. We offer uniquely interesting and meaningful work, opportunities for growth, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits. This is work that transforms the lives of patients, and the careers of those who do it. The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept. In the role as a Scientist within In Vivo Pharmacology, the ideal candidate: Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology. Manages in vivo studies conducted at contract research organizations (CROs) Serves as an in vivo pharmacology representative on program and platform teams
Requirements
- Bachelor’s Degree
- 5+ years of academic and / or industry experience
- Master’s Degree
- 3+ years of academic and / or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences
- No experience necessary
- Extensive mouse handling experience, including common dosing routes and tissue collection from central nervous system (CNS) and peripheral tissues required
- Proficiency in standard molecular biology, biochemical, immunohistochemical, and/or muscle physiology assays required
Nice To Haves
- PhD in Neuroscience or related field is required.
- Expertise and practical experience in one or more of the following: Neurodegenerative disease, such as Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease, particularly with respect to animal modeling
- Neuromuscular disease, such as amyotrophic lateral sclerosis (ALS) and muscular dystrophies, particularly with respect to animal modeling
- RNA biology and splice modulation
- Genetic medicines, particularly the delivery of siRNAs and/or ASOs across the blood-brain barrier (BBB)
- Experience with rodent stereotaxic surgery
- Familiarity with in vivo bioluminescence imaging
- Familiarity with transcriptomics and/or proteomics
- Experience working with contract research organization (CROs)
- Strong organizational and communication skills
- Ability to work independently and as part of a team
- Detail-oriented with a commitment to scientific rigor and reproducibility
- Adaptability in a fast-paced, collaborative research environment
Responsibilities
- Performs and directs in vivo pharmacology studies in mice, inclusive of in-life dosing (IV, SC, IP, PO, ICV), tissue collection, and tissue processing
- Performs and analyzes pharmacodynamic (PD) and efficacy readouts, including mRNA/protein expression levels, neuropathology, transcriptomics, and physiology.
- Manages in vivo studies conducted at contract research organizations (CROs)
- Serves as an in vivo pharmacology representative on program and platform teams
Benefits
- wellbeing support
- retirement and financial protection benefits
- insurance offerings (medical, dental, vision, life and disability)
- Flexible Time Off (FTO)
- 11 paid company holidays each year
- 160 hours of paid vacation annually for new hires
- 3 optional holidays
- paid sick leave
- up to two paid volunteer days per year
- summer hours flexibility
- leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs
- annual Global Shutdown between Christmas Day and New Year's Day
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What This Job Offers
Job Type
Full-time
Career Level
Senior
