Senior Scientist I, Biomolecular Interactions

AbbVie • Worcester, MA

2d • $96,500 - $183,500

About The Position

AbbVie's Biotherapeutics and Genetic Medicine, Protein Sciences Group is seeking a skilled scientist to join its Biomolecular Interaction Team. The role supports Discovery Research therapeutic areas and projects by providing analytical and functional characterization of biopharmaceutical products, including monoclonal antibodies, multispecifics, and antibody-like biologics. The scientist will use high-throughput biologics screening and characterization methods, including SPR, BLI, ELISA, and FACS, and contribute scientific expertise in protein sciences and antibody discovery on cross-functional teams.

Requirements

• PhD, MS, or BS in Biochemistry, Biomedical Engineering, or a related field, with typically 0–4 years of experience for a PhD, 8+ years for an MS, or 10+ years for a BS.
• Experience characterizing biologics analytically and functionally using Surface Plasmon Resonance platforms, such as Biacore and Carterra.
• Experience with high-throughput biologics screening using biochemical, biophysical, and cell-based methods.
• Excellent organizational skills and the ability to manage multiple projects simultaneously.
• Ability to work as a team player in a fast-paced, multidisciplinary environment.
• Ability to adapt to rapid changes in project priorities and timelines.
• Goal-oriented team player with excellent verbal and written communication skills and a strong can-do attitude.

Nice To Haves

• Broad technical knowledge of analytical, biophysical, and structural methods such as SEC, MS, HDX-MS, X-ray crystallography, DSF, and DLS.
• Extensive knowledge of related functional areas, including protein structure and function, antibody engineering, protein production, and analytics.
• Experience managing internal and external collaborations.

Responsibilities

• Independently develop and execute SPR assays using Biacore and Carterra platforms to generate objective selection criteria for panels of antibodies, multispecifics, and antibody-like biologics.
• Evaluate and integrate protein-protein interaction technologies, such as SPR, BLI, and ELISA, to support therapeutic candidate selection.
• Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop knowledge of antibody sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Independently identify and solve technical problems, and develop new approaches to advance characterization and screening technologies.
• Serve as a biologics lead for cross-functional teams and contribute scientific insights to projects across therapeutic areas.
• Provide project updates, analysis, and advice to cross-functional teams and senior management.
• Present original work internally and at scientific conferences, and potentially author or co-author peer-reviewed scientific papers or patents.

Benefits

• Paid time off, including vacation, holidays, and sick leave.
• Medical, dental, and vision insurance for eligible employees.
• 401(k) for eligible employees.
• Eligibility to participate in short-term incentive programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior