Senior Scientist I, Biomolecular Interactions

AbbVie • Worcester, MA

1d

About The Position

AbbVie’s Biotherapeutics and Genetic Medicine, Protein Sciences Group is seeking a scientist to join its Biomolecular Interaction Team. The role supports Discovery Research therapeutic areas and projects through analytical and functional characterization of biopharmaceutical products, including monoclonal antibodies, multispecifics, and antibody-like biologics. The scientist will use high-throughput biologics screening and characterization methods and contribute to protein sciences and antibody discovery in a collaborative, cross-functional environment.

Requirements

• PhD, MS, or BS in Biochemistry, Biomedical Engineering, or a related field.
• Typically 0–4 years of experience with a PhD, 8 or more years with an MS, or 10 or more years with a BS.
• Experience characterizing biologics analytically or functionally using SPR platforms such as Biacore and Carterra.
• Experience with high-throughput biologics screening using biochemical, biophysical, and cell-based methods.
• Excellent organizational skills and ability to manage multiple projects simultaneously.
• Ability to work as a team player in a fast-paced, multidisciplinary environment and adapt to changing project priorities and timelines.
• Excellent verbal and written communication skills and a goal-oriented, can-do attitude.

Nice To Haves

• Broad technical knowledge of analytical, biophysical, and structural methods such as SEC, MS, HDX-MS, X-ray crystallography, DSF, and DLS.
• Extensive knowledge of protein structure and function, antibody engineering, protein production, and analytics.
• Experience managing internal or external collaborations.

Responsibilities

• Independently develop and execute SPR assays using Biacore and Carterra platforms to establish objective selection criteria for antibody, multispecific, and antibody-like biologic panels.
• Evaluate and integrate protein-protein interaction technologies, including SPR, BLI, and ELISA, to support therapeutic candidate selection.
• Implement high-throughput epitope binning for large monoclonal antibody panels and develop knowledge of antibody sequence/function relationships.
• Perform antibody Fc characterization studies to support regulatory submissions.
• Independently identify and solve technical problems and develop approaches to advance characterization and screening technologies.
• Serve as a biologics lead for cross-functional teams and contribute scientific insights to projects across therapeutic areas.
• Provide project updates, analysis, and advice to cross-functional teams and senior management.
• Present original work internally and at scientific conferences; potentially author or co-author peer-reviewed papers or patents.

Benefits

• Paid time off, including vacation, holidays, and sick leave.
• Medical, dental, and vision insurance.
• 401(k).
• Eligibility to participate in short-term incentive programs.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior