Senior Scientist, Discovery Biology Oncology

Bristol Myers Squibb • Needham, MA

1d • $137,570 - $166,706 • Onsite

About The Position

The Oncology Thematic Research Center at BMS is a key research and early development engine, responsible for the discovery and development of novel oncology therapeutics for patients. Centered at our state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current therapies. With a deep understanding of the causal human biology, we are able to leverage our multiple modality platforms to best match the modality to the mechanism and desired outcome. We are a fully integrated drug discovery through translational and early clinical development organization which exploits state-of-the-art in vitro, in vivo and ex-vivo models of Cancer biology and Immuno-oncology to identify and validate targets. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. We are optimally positioned to complement the world-class translational expertise, biology and leading academic research centers in the area. Our Bristol Myers Squibb research site in Cambridge Crossing will help us continue to deliver on our mission, positioning the company and our scientists in the heart of a vibrant ecosystem of world-class science, innovation, and business opportunities. We are seeking an experienced individual with cancer research and small molecule oncology drug discovery expertise to join the Discovery Biology team within the Oncology Thematic Research Center at Bristol Myers Squibb in Cambridge, MA. The qualified candidate is a highly motivated, interactive, and creative scientist and with the ability to work across a highly matrixed organization to advance programs from target discovery and validation to lead optimization, selection of drug candidate and IND-enabling biology related activities. The candidate will be involved in leading and executing biology activities that will help advance programs from early stages all the way through IND filling. In addition, the individual will coordinate with other functions, such as informatics and predictive science, lead discovery and optimization, in vivo pharmacology, and translational research teams to design/execute work related to patient stratification, identification of appropriate PD markers and assay development/transfer for miniaturization, among others to ensure timely project advancement. This individual will be responsible for designing and executing strategies and experimental studies related to the decisional progress of our programs.

Requirements

• Bachelor’s Degree 7+ years of academic and / or industry experience
• Master’s Degree 5+ years of academic and / or industry experience
• Ph.D. or equivalent advanced degree in the Life Sciences 2+ of academic and / or industry experience

Nice To Haves

• PhD degree with extensive knowledge and track record in cancer research and industry experience in small molecule oncology drug discovery, or BS/MS degree with 5-7+ years in the industry setting
• Experience leading biology activities for small molecule drug discovery programs from project initiation through toxicology studies
• Proficient with molecular and cellular biology related techniques, including but not limited to 2D/3D/spheroid cell culture and related cellular assays, Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), ELISA, MSD and/or HTRF assays, colony formation assay, processing of DNA/RNA/protein, IP/Co-IP
• Experienced in cell line model engineering using genetic and/or pharmacologic tools
• Willingness to take risk and tackle difficult projects head-on
• Demonstrated ability to think creatively and differently to solve challenging problems
• Ability to efficiently manage and prioritize multiple projects, coordinating in-house research with collaborative work
• Ability to summarize and interpret scientific data in a clear, concise, and accurate manner
• Attention to detail with excellent organizational and record keeping skills is a requirement
• Excellent oral and written communication skills.
• A strong team player with ability to communicate well with team members

Responsibilities

• Will be an experienced biology leader, who has demonstrated ability to lead biology strategy and activities within small molecule oncology drug discovery teams
• Applies extensive scientific knowledge and technical skills to oversee and conduct molecular and cellular biology related studies to better understand target and disease biology
• Leverages current and new technologies for function-based characterization for small molecule hit validation, mechanism of action understanding, and compound triaging
• Expertise related but not limited to 2D/3D/spheroid cell culture and related cellular assays, Western blot and/or JESS, qRT-PCR, flow cytometry, proliferation and/or cytotoxicity assays (CyQuant, CTG, apoptosis, IncuCyte, etc.), high-content imaging (e.g. Phenix), ELISA, MSD and/or HTRF assays, colony formation assay, processing of DNA/RNA/protein, IP/Co-IP
• Experience generating and characterizes relevant cell models, such as using genetic tools (CRISPR, shRNA, siRNA, lentiviral mediated target overexpression, etc.)
• Collaborates with rest of biology team members as well as other functional area leads e.g. pharmacology, DMPK, informatics and predictive science, etc.
• Makes presentations in multidisciplinary and governance meetings, logically presenting data and interpretation to convey clear, key messages
• Has a strong publication record in impactful journals

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree