Senior Scientist 2 - Chemical Research & Development

Cambrex•High Point, NC

16h

About The Position

The Senior Scientist 2 position focuses on optimizing existing chemical routes and developing alternative chemistry for key synthetic intermediates and active pharmaceutical ingredients (APIs). The role carries out multistep chemical synthesis and product isolation and purification in the laboratory, independently or as part of an integrated team. The scientist uses modern analytical tools to determine product identity and purity, communicates with clients in regular team meetings, and prepares research and development reports at project completion. The role works with manufacturing and GMP operations to coordinate project equipment and activities. It includes handling hazardous materials and wastes, applying the company’s chemical hygiene plan, maintaining a safe and clean laboratory, and recognizing hazardous-material emergency situations. The position may assist with client regulatory guidance with manager input.

Requirements

Ph.D. in Chemistry or a related field with at least 2 years of experience; or an M.S. in Chemistry or a related field with at least 6 years of experience; or a B.S. in Chemistry or a related field with 10 years of laboratory experience.
Hands-on experience in pharmaceutical or chemical process development.
Strong understanding of organic chemistry principles and some process development experience.
Understanding of cross-functional disciplines, including analytical chemistry and engineering.
Demonstrated understanding of GMP as it relates to current work.
Understanding of modern organic synthesis methodologies.
Fundamental understanding of modern analytical and spectroscopic techniques.
Ability to perform synthesis and purification on scales from milligrams to several kilograms.
Demonstrated ability to use and train others on HPLC and GC, investigate root-cause issues, and a good understanding of MS; experience with automated reactors and possibly in-situ reaction monitoring.
Good written and oral communication, interpersonal, and organizational skills, and ability to work in a diverse team environment.
Ability to handle client requests with manager review and help lead investigations with manager support.
Ability to self-organize and manage time with or without supervision.
Ability to write and review reports and technical documents with minimal errors, and maintain a current laboratory notebook while practicing good documentation practices.
Proficiency with Microsoft SharePoint, Word, Excel, PowerPoint, and ChemDraw.
Ability to read, understand, apply, and communicate written and verbal information about hazardous-waste handling and management.

Nice To Haves

Pharmaceutical experience.

Responsibilities

Carry out multistep organic syntheses, isolation, and purification of targeted products under the supervision or direction of a senior team member.
Perform laboratory synthesis and purification at scales ranging from milligrams to several kilograms.
Use analytical and spectroscopic techniques to assess products and interpret relevant data and spectra.
Coordinate project activities and resource use while requiring minimal supervision.
Write comprehensive project reports for internal and customer use.
Assist in advising clients on key regulatory guidance, with manager input.
Promote teamwork and cooperation within the group.
Conduct laboratory operations safely, follow the chemical hygiene plan, and maintain safety awareness and safe work practices.
Coordinate project-related equipment and activities with manufacturing and GMP operations.
Maintain a clean and safe laboratory work area.
Read, understand, apply, and communicate information about handling and managing hazardous materials and wastes; complete required training and recognize related emergency situations.
Use, train others on, and investigate root-cause issues involving HPLC and GC; work with MS, automated reactors, and potentially in-situ reaction monitoring.
Handle client requests with manager review and help lead workplace investigations with manager support.
Maintain current laboratory notebooks and write and review technical reports and documents in accordance with good documentation practices.
Participate in internal project team meetings, submit key technical reports, and organize group-level initiatives.
Support operational excellence initiatives and locally support changes associated with broader company initiatives.