Senior Scientist, Chemical Development

Nurix•Brisbane, CA

17h•Onsite

About The Position

The Senior Scientist, Chemical Development will own chemical development activities across Nurix’s portfolio, including process development and manufacture of regulatory starting materials (RSMs) and support for production of drug substance (DS) for clinical trial materials, with a focus on early development. The role includes route scouting for pre-clinical and clinical candidates and developing robust, scalable processes to support initial scale-up for animal studies. The scientist will spend up to 50% of their time in the lab supporting early route scouting and discovery scale-up toward CMC transition. They will author technology-transfer documents and work with CROs and CDMOs to reproduce chemistry efficiently across sites. The role also supports RSM and DS manufacturing and candidate-compound scale-up at CRO/CDMO sites, phase-appropriate process characterization, identification of critical quality attributes, and implementation of controls to ensure regulatory compliance and consistent DS quality. The scientist will prepare or review CMC sections of regulatory submissions and may travel up to 10% of the time. This is an onsite position in Brisbane, California, in a small, entrepreneurial environment with broad responsibilities. Nurix Therapeutics is a clinical-stage biopharmaceutical company focused on discovering, developing, and commercializing targeted protein degradation medicines for cancer and inflammatory diseases.

Requirements

PhD with 2–7 years of experience, or MS with 5 or more years of experience.
Advanced degree in Organic Chemistry, Chemical Engineering, Pharmaceutical Chemistry, Pharmaceutics, Pharmaceutical Science, or a related scientific discipline.
Strong working knowledge of synthetic organic chemistry and ability to apply it to route development and rapid synthetic triage.
Experience leveraging US and international CROs/CMOs to manufacture RSMs and DS and meet aggressive timelines.
Ability to analyze experimental and analytical data.
Ability to identify and resolve critical issues.
Experience implementing technical, strategic, and operational plans.
Excellent written and verbal communication skills.
Exceptional interpersonal and management skills to collaborate with and direct the work of others on assigned projects, including internal teams and external collaborators.
Strong team orientation.
Highly motivated, collaborative, solutions- and results-oriented, hands-on, resourceful, and open to diverse points of view.

Nice To Haves

2–5 years of relevant experience in a pharmaceutical or biotechnology CMC/cGMP environment.
Experience with payload linker development for ADCs.

Responsibilities

Own chemical development activities across the portfolio, including process development and manufacture of regulatory starting materials (RSMs) and support for production of drug substance (DS) for clinical trial materials.
Scout routes for pre-clinical and clinical candidates.
Develop robust, scalable processes to support initial scale-up for animal studies.
Spend up to 50% of the time in the lab supporting early route scouting and discovery scale-up toward CMC transition.
Author technology-transfer documents and work with CROs/CDMOs to reproduce chemistry across sites.
Support RSM and DS manufacturing activities at CRO/CDMO sites, including scale-up of candidate compounds to support candidate selection during drug discovery.
Support phase-appropriate process characterization, identify critical quality attributes, and implement controls, including selection and justification of RSMs.
Help ensure CROs and CMOs use systems and processes that comply with relevant regulatory standards and provide consistent DS quality.
Prepare and/or review CMC sections of INDs, CTAs, NDAs, MAAs, and other regulatory submissions.
Travel up to 10%.