Principal Scientist 1 - Chemical Research & Development

Cambrex•High Point, NC

16h

About The Position

The Principal Scientist 1 role in Chemical Research and Development focuses on optimizing existing chemical routes and developing alternate chemistry for key synthetic intermediates and APIs. The scientist carries out multistep chemical synthesis and product isolation and purification in the laboratory, independently or as part of an integrated team, and uses modern analytical tools to determine product identity and purity. The role includes communicating with clients in regular team meetings and preparing R&D reports at project completion. The position works closely with chemistry and analytical laboratory staff, manufacturing, and GMP operations to coordinate project activities, resources, equipment, and related work. It also contributes to mentoring, local project leadership, operational excellence, and implementation of company initiatives. Laboratory work is performed with attention to safety, chemical hygiene, responsible chemical disposal, regulatory compliance, and maintaining a clean and safe work area.

Requirements

Ph.D. in Chemistry or a related field with at least 6 years of experience; or M.S. in Chemistry or a related field with at least 10 years of experience; or B.S. in Chemistry or a related field with 12 years of laboratory experience.
Hands-on experience in pharmaceutical or chemical process development.
Strong understanding of modern organic synthesis methodologies and advanced organic chemistry and process development theories.
Thorough understanding of modern analytical and spectroscopic techniques, including the ability to interpret data and spectra.
Higher-level understanding of cross-functional disciplines, including analytical chemistry and engineering.
Demonstrated understanding of GMP and the fundamental industrial regulatory landscape; good understanding of site SOPs and regulatory CMC concerns, with the ability to address client questions relevant to clinical packages.
Advanced knowledge of HPLC, GC, MS, automated reactor platforms, and in-situ reaction monitoring, including the ability to train others and troubleshoot equipment.
Strong problem-solving skills and ability to lead investigations.
Effective time management and ability to handle projects without supervision, with regular manager check-ins.
Demonstrated mentorship and peer-development experience, ability to support partner lines, and ability to contribute to departmental initiatives.
Ability to author and review technical documents with minimal RFT errors, write new SOPs with manager assistance, and maintain a current laboratory notebook while practicing GDP.
Excellent verbal, written, and interpersonal communication skills; organizational skills; and ability to work in a diverse team environment.
Proficiency with Microsoft SharePoint, Word, Excel, and PowerPoint, and ChemDraw.
Ability to perform active work involving exertion of up to 50 pounds of force occasionally, or force frequently or constantly to lift, carry, push, pull, or otherwise move objects.
Ability to walk and stand regularly and meet visual acuity, talking, and fingering requirements.
Ability to use basic PPE regularly, including supplied-air respirators, negative-pressure respirators, gloves, safety glasses, and shielding clothing.

Nice To Haves

Pharmaceutical experience is preferred.

Responsibilities

Design and carry out multistep organic syntheses, isolation, and purification of targeted products.
Conduct literature searches for target compounds and use the findings to design alternate synthetic routes; stay current with scientific literature and discuss findings with colleagues.
Perform laboratory synthesis and purification from milligram to several-kilogram scales, and design and implement process modifications.
Manage projects and timelines efficiently, including working independently with regular check-ins with a manager.
Author and review comprehensive project reports and technical documents for internal and customer use.
Work with chemistry and analytical laboratory staff to coordinate project activities and resource use.
Promote teamwork and cooperation within the group.
Conduct laboratory operations safely, follow the chemical hygiene plan and safe work practices, dispose of chemicals responsibly, and comply with applicable federal, state, and local regulations.
Communicate effectively in writing, verbally, and in presentations; participate in customer project meetings and often lead technical client calls.
Coordinate project-related equipment and activities with manufacturing and GMP operations.
Maintain a clean and safe laboratory work area.
Mentor and develop peers and partner lines, support departmental initiatives, and lead local project teams.
Participate in operational excellence initiatives and support implementation of Cambrex system-level changes and initiatives.