Senior Scientist 1, In Vitro Pharmacology

Crinetics Pharmaceuticals•San Diego, CA

2d•Onsite

About The Position

Crinetics is a pharmaceutical company based in San Diego, California, developing much-needed therapies for people with endocrine diseases and endocrine-related tumors. We have a prolific discovery engine and a robust preclinical and clinical development pipeline. We are driven by science with a patient-centric and team-oriented culture. Crinetics is known for its inclusive workplace culture. We are also a dog-friendly workplace. This is an exciting time to join Crinetics as we shape our organization into the world’s premier fully integrated endocrine company from discovery to patients. Join our team as we transform the lives of others. We are seeking a highly motivated and collaborative Senior Scientist 1 with experience in GPCR pharmacology and drug discovery to join our growing and dynamic in vitro pharmacology team. The successful candidate will engineer and execute in vitro mechanism of action (MoA) and translational studies, while pioneering new technology and assay development initiatives to advance the in vitro pharmacology department’s capabilities.

Requirements

Ph.D. in Pharmacology, Biochemistry, Biology, or related discipline with a minimum of 3-5 years of relevant experience. Applicants with BS or MS degrees must demonstrate a minimum of 11 years of relevant experience.
Demonstrated expertise of small molecule GPCR pharmacology, including theoretical understanding of signaling models, mechanisms, and experimental design.
Proven technical expertise in developing and executing biochemical, cellular, and radioligand binding assay systems with a focus on high-quality data generation.
Ability to leverage existing literature to develop methods, protocols, and technologies that advance pharmacological capabilities.
Outstanding experimental design and problem-solving skills, with a rigorous approach to complex data analysis.
Proven ability to thrive in a fast-paced, dynamic environment and pivot effectively as program priorities evolve.
Exceptional written and verbal communication skills, with a proven ability to collaborate effectively across multidisciplinary teams.
A strong work ethic characterized by detail-orientation, reliability, and an enthusiasm for both high-level laboratory work and complex data analysis.

Responsibilities

Design, develop, and execute in vitro pharmacology assays (e.g., biochemical, cell-based functional, and radioligand binding) to characterize GPCR mechanism and signaling.
Evaluate and establish novel in vitro technologies to advance drug discovery.
Perform translational experiments that bridge in vitro activity with predicted human outcomes.
Engineer and maintain multiple mammalian cell lines in culture to support ongoing assay needs.
Generate high quality, reproducible data, and ensure meticulous documentation of protocols and results in an electronic laboratory notebook.
Critically analyze and interpret complex data into meaningful understanding of ligand activity and mechanism of action.
Explore and establish PK/PD relationships by correlating in vitro pharmacological data with in vivo animal efficacy results.
Uphold scientific integrity by performing rigorous data scrutiny on complex data sets and ensuring all work meets quality standards.
Synthesize and effectively communicate findings to multidisciplinary teams through informal updates, formal presentations, and reports.
Contribute to scientific publications and technical documentation.
Mentor junior staff through hands-on technical instruction, creation of standardized SOPs, and data oversight.
Ensure total compliance with institutional safety standards, data management policies, and laboratory practices.
Other duties as assigned.