TEMP Scientist, In Vitro Pharmacology

Neurocrine Biosciences•San Diego, CA

10d

About The Position

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. This role will be primarily responsible for developing, optimizing, and executing weekly in vitro pharmacology assays, as well as conducting molecular mechanism exploration and receptor occupancy studies in support of lead optimization campaigns in the context of multidisciplinary teams. The role will involve critical analysis of assay data to guide the identification and optimization of lead compounds, alongside thorough documentation and presentation of results. Our collaborative, fast-paced work environment emphasizes efficiency and continuous improvement.

Requirements

BS/BA degree and 2 years of relevant experience (5+ years of experience preferred), including practical experience with a broad range of in vitro biological assays
MS/MA degree in Molecular Pharmacology or related field and some relevant experience (2+ years of experience preferred)
PhD in Molecular Pharmacology or related field with similar experience
Collaborative and highly motivated
Hands-on experience conducting in vitro assays for diverse pharmacological targets, such as SLC transporters, GPCRs, ion channels, and kinases
Experience and knowledge of mammalian cell culture and aseptic techniques
Outstanding experimental design, problem-solving, and data analysis skills
Ability to meet deadlines
Experience using laboratory automation, inventory systems, data analysis (curve fitting, determination of potency, affinity, efficacy) and informatics systems
Enthusiasm for developing and expanding technical and theoretical knowledge base
Working knowledge of Excel, GraphPad Prism and Spotfire software helpful
Excellent communication (written and verbal), time management, organizational and interpersonal skills to ensure operational excellence of daily laboratory needs
Embody Neurocrine’s core values of Passion, Collaboration, Tenacity, Innovation, and Integrity

Nice To Haves

Experience with radioligand binding assays preferred
Expertise in molecular pharmacology and/or chemical biology preferred
Working knowledge of LIMS systems preferred

Responsibilities

Perform routine assays to support lead identification campaigns
Develop, optimize, and conduct functional and binding assays to support profiling of molecules and mechanism of action studies
Support in vivo and ex vivo receptor occupancy efforts
Demonstrate clear understanding of assay mechanisms, workflow logistics and scientific background
Assist with generating and maintaining cell lines and perform assays for their characterization
Rapidly learn and implement new assays and analysis methods
Track and document assay performance
Assist with process improvements to enhance efficiency and research quality
Effectively multitask and advance various projects simultaneously without compromising data quality or reproducibility
Work independently as well as in a team environment toward timely execution of shared team deliverables