Scientist, In Vivo Pharmacology

Alnylam Pharmaceuticals•Cambridge, MA

1d•Onsite

About The Position

We are seeking a highly motivated Scientist, In Vivo Pharmacology to support the development of innovative therapeutics for autoimmune diseases and oncology. The ideal candidate will have strong hands-on experience in preclinical in vivo models and a solid understanding of immunology and translational research. In this role, you will design and execute in vivo studies, perform downstream ex vivo analyses, and collaborate cross-functionally (including with CRO partners) to advance drug discovery programs. In vivo models are critical for evaluating therapeutic efficacy, immune modulation, and translational relevance in both autoimmune and tumor settings. This position is onsite and will be primarily located in Cambridge, MA.

Requirements

PhD, Masters, Bachelors, in Immunology, Biology, Pharmacology, or a related discipline.
PhD 0+, Masters 10+ years, Bachelors 12+ of hands-on experience in in vivo pharmacology within biotech or pharmaceutical settings.
Demonstrated expertise in autoimmune disease models and tumor models, including study design, execution, and data interpretation.
Proficiency in common in vivo techniques: animal handling and dosing (multiple routes), tumor implantation and measurement, disease scoring in autoimmune models, necropsy and tissue collection.
Experience analyzing downstream endpoints such as flow cytometry, cytokine assays, molecular biomarkers, qPCR, and ELISA assays.
Demonstrated ability to independently design experiments, troubleshoot, and manage multiple studies simultaneously.
Strong organizational skills, attention to detail, and commitment to scientific rigor and reproducibility.
Excellent communication and interpersonal skills, with the ability to effectively collaborate across multidisciplinary teams.

Responsibilities

Design and execute in vivo pharmacology studies in autoimmune and tumor models.
Perform in vivo procedures including animal dosing (IV, IP, SC, PO), tumor implantation, disease induction, and tissue collection.
Conduct ex vivo analyses from collected tissues, including: Flow cytometry for immune profiling, qPCR for gene expression analysis and cytokine and biomarker assessment.
Analyze and interpret data (tumor growth, disease scores, immune readouts) and prepare clear study summaries and presentations.
Collaborate with internal teams and external CROs to design, execute, and monitor outsourced studies; ensure data quality and timely delivery.
Contribute to study design, including model selection, dosing strategies, and endpoint definition.
Maintain accurate documentation in compliance with regulatory and ethical standards (e.g., IACUC).