Senior Research Scientist I, Antibody Engineering and Characterization

Broad Institute•Cambridge, MA

1d•Onsite

About The Position

The Center for the Development of Therapeutics (CDoT), embedded within the Broad Institute, is a collaborative organization of drug discovery scientists that translates biological insights into drug discovery projects. CDoT partners with academic and industry organizations to validate targets and identify leads across a range of disease areas, using approaches that include genomics, biology, high-content imaging, chemistry, single-domain antibody discovery, and machine learning. CDoT is seeking a passionate, highly motivated Senior Research Scientist I to join its growing Biologics team. The successful candidate will bring extensive experience in biologics and multispecific engineering, analytical characterization, and advancing biologics drug discovery programs from inception through proof of concept and candidate nomination. The role involves leading integrated antibody engineering campaigns and collaborating with internal teams and external academic and industry partners.

Requirements

PhD in immunology, molecular biology, biochemistry, protein engineering, or a related discipline.
At least 5 years of relevant post-PhD industry experience in biologics drug discovery.
Deep technical expertise in antibody biology, structure and function, discovery platforms, and therapeutic antibody optimization.
Experience with complex biologics formats, such as T cell engagers, TCR engagers, bispecific or multispecific antibodies, ADCs, CAR-T, or immunocytokine fusions.
Hands-on experience with structure-guided antibody engineering and modeling software such as Schrödinger, MOE, or PyMOL.
Expertise in antibody characterization assays and platforms, including affinity determination, epitope binning, competition assays, specificity profiling, and developability assessment using Biacore, Carterra, Octet, ELISA, HPLC, DLS/SLS, and related technologies.
Experience with biologics expression and purification using chromatographic methods such as affinity, SEC, IEX, and HIC.
Ability to design, manage, and critically evaluate outsourced biologics discovery, production, and characterization workflows at CROs and to work on multiple projects simultaneously.
Self-motivated, detail-oriented, results-focused, and team-oriented, with creativity and strong problem-solving skills.
Clear and effective communication and interpersonal skills to collaborate with project teams, peers, and management.

Nice To Haves

Experience with display platforms such as phage or yeast for antibody discovery and optimization.
Experience managing direct reports and developing talent.
Experience with LC-MS characterization of biologics.
Experience implementing AI/ML in biologics drug discovery workflows.

Responsibilities

Lead integrated antibody and biologics engineering campaigns from early concept through lead identification and optimization.
Design, execute, and oversee antibody engineering and optimization workflows, including affinity maturation, humanization, format conversion, Fc engineering, expression, purification, and characterization.
Engineer and evaluate antibodies in multiple therapeutic formats, including IgG, Fab, scFv, bispecific and multispecific antibodies, T cell engagers, TCR engagers, CAR-T-related formats, and other novel modalities.
Characterize antibody candidates using biochemical, biophysical, and functional assays to assess binding, affinity, specificity, epitope diversity, developability, potency, and mechanism of action.
Collaborate with industry and academic partners and CDoT team members, including protein sciences and RABIT binder discovery, on cross-functional projects.
Design, manage, and critically evaluate outsourced biologics drug discovery, production, and characterization workflows at CROs.
Work on multiple projects simultaneously.