Senior Scientist, Antibody Discovery
About The Position
SystImmune is seeking a highly skilled and motivated Senior Scientist to join its Antibody Discovery Group. The successful candidate will advance antibody discovery efforts using techniques including immunogen design, B-cell sorting, flow cytometry, ELISA, and yeast library screening. This role offers the opportunity to contribute to the development of novel therapeutic antibodies in a dynamic and innovative environment. The position involves designing and executing antibody discovery campaigns from immunization through lead delivery, isolating and characterizing antibody candidates, developing and performing screening assays, analyzing data, and collaborating with cross-functional teams on project planning and strategy. The role also includes maintaining accurate records, complying with safety requirements, and supporting lab organization.
Requirements
- Ph.D. in Immunology, Molecular Biology, Biochemistry, or a related field.
- At least 5 years of industry experience, including some applicable postdoctoral research experience.
- 3–7 years of hands-on experience in B-cell sorting and screening through flow cytometry, ELISA, and bio-layer interferometry.
- Proficiency in flow cytometry and cell sorting techniques.
- Experience in biolayer interferometry, including affinity, avidity, and binning, or similar assays.
- Strong background in ELISA assay development and optimization.
Nice To Haves
- A proven track record working with Sony cell sorters or similar instruments.
- Experience with single-cell analysis platforms such as Beacon.
- Experience in antibody discovery and development.
- Experience in NGS library preparation and BCR repertoire analysis.
- Expertise in molecular biology techniques related to yeast display libraries, including preparation, culture, and screening.
Responsibilities
- Design and execute antibody discovery campaigns from immunization to lead delivery.
- Perform high-throughput sorting to isolate specific B-cell populations.
- Design, execute, and analyze FACS experiments to validate and characterize antibodies.
- Develop, optimize, and perform ELISA, BLI, and flow cytometry assays for antibody screening and specificity testing.
- Conduct yeast display library screening to identify and analyze antibody candidates.
- Analyze experimental data and prepare detailed reports and presentations.
- Work with cross-functional teams and contribute to project planning and strategy.
- Maintain accurate records, ensure safety compliance, and contribute to lab organization.
Benefits
- 100% paid employee premiums for medical, dental, and vision insurance.
- Short-term disability insurance.
- Long-term disability insurance.
- 401(k) plan with a 50% company match of up to 3%, with a five-year vesting schedule.
- 15 PTO days per year.
- Sick leave.
- 11 paid holidays.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
