Senior Research Associate, In Vivo Pharmacology
Arbor Biotechnologies•Cambridge, MA
•$85,000 - $95,000•Onsite
About The Position
The Senior Research Associate, In Vivo Pharmacology carries out in vivo studies supporting gene-editing programs for neurodegenerative diseases. The role takes studies from dosing through tissue collection and molecular readout, producing data that informs preclinical and IND-enabling decisions. The position reports to the Senior Scientist, In Vivo Pharmacology and is on-site in Cambridge, typically 4–5 days per week.
Requirements
- Bachelor’s degree in pharmacology, biology, neuroscience, molecular biology, or a related field with 3+ years of industry experience, or a master’s degree with 1+ year of industry experience.
- Hands-on experience running in vivo rodent studies, including dosing, monitoring, blood collection, tissue harvest, and necropsy.
- Experience dosing rodents by intravenous, retro-orbital, or comparable routes.
- Experience processing animal tissues and biological samples for molecular, biochemical, or pharmacodynamic endpoints.
- Experience running molecular and biochemical assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
- Experience managing samples and timelines across more than one study at a time.
Nice To Haves
- Flow cytometry experience.
- Experience supporting IND-enabling studies.
Responsibilities
- Run in vivo pharmacology studies in rodents, including dosing, monitoring, clinical observations, blood collection, tissue harvest, and necropsy.
- Set up and schedule studies and coordinate between the laboratory and animal facility.
- Process tissues and biological samples and isolate DNA, RNA, and protein for molecular, biochemical, and pharmacodynamic analysis.
- Run assays such as qPCR/ddPCR, RT-qPCR, Western blot, Simple Western/Jess, ELISA, or RNAscope.
- Analyze, interpret, and graph study and assay data in GraphPad Prism and other analysis tools.
- Present findings, study progress, and data summaries to project teams and cross-functional collaborators.
- Keep study records, sample inventories, and protocols accurate and current.
Benefits
- Bonus eligibility for every employee.
- New-hire equity.
- The company pays about 90% of medical, dental, and vision premiums.
- The company funds the full deductible on its HSA plan.
- 12 weeks of parental leave at full pay.
- Paid parking or transit.
- 401(k) match.
- Discretionary time off.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
