Senior Research Associate, Chemical Development
About The Position
Novo Nordisk Global Nucleic Acid Therapies (GNAT) is seeking a scientist to join its CMC Chemical Development team at the Boulder, Colorado facility. The role supports therapeutic programs in multiple disease areas by developing scalable processes for oligonucleotide programs. The candidate will serve as a technical resource for scalable synthesis, work-up, purification, and isolation solutions that improve purity, yield, reproducibility, throughput, and environmental impact. The work involves research and development across oligonucleotide and organic chemistry projects, process development and optimization, and support for scale-up and technology transfer into manufacturing. The position collaborates with Chemical Development, Technical Operations, Quality, Regulatory, RNAi Early Development, and internal and external partners.
Requirements
- BA/BS degree in Chemistry, Biology, or a related field with at least 2 years of relevant industrial experience; or a Master’s degree with 0+ years of relevant industrial experience; or a high school diploma with at least 10 years of relevant laboratory experience.
- Ability to follow moderately complex technical instructions independently and with reduced supervision.
- Experience with experimental design, execution, and analysis with limited supervision.
- Demonstrable laboratory skills in synthetic organic chemistry and/or oligonucleotide synthesis, characterization, and purification.
- Solid understanding of synthetic organic chemistry and/or oligonucleotide-relevant reactions and mechanisms.
- Detail-oriented in data analysis and project timelines.
- Self-motivated, proactive approach.
- Excellent writing and communication skills, with the ability to work independently and with cross-functional teams.
- Ability to thrive in a multidisciplinary, fast-paced research environment with tight deadlines.
- Ability to lift 0–10 lbs.
Responsibilities
- Provide research and development support for chemical development projects using techniques for preparing and analyzing oligonucleotides or nucleic acids.
- Conduct laboratory work safely, cleanly, and efficiently.
- Characterize starting materials, intermediates, and synthesized molecules using techniques such as HPLC, LCMS, NMR, GC, KF, and UV-Vis.
- Develop and optimize chemical transformations, including reaction conditions, work-up, purification, and isolation; ensure process robustness and reproducibility.
- Collaborate with Technical Operations to develop and optimize manufacturing processes for oligonucleotide intermediates, reagents, and final API.
- Document and summarize results in laboratory notebooks and written reports, and draw valid conclusions from experimental variables.
- Contribute to team knowledge through scientific literature reviews and discussions.
- Operate, maintain, and troubleshoot common laboratory equipment.
- Author development and research reports for internal and external teams with reduced input.
- Complete assignments to defined deadlines and schedules with minimal instructions.
- Build and maintain effective working relationships with Chemical Development, Technical Operations, and internal and external partners.
Benefits
- Company bonus based on individual and company performance.
- Long-term incentive compensation and/or company vehicles depending on position level or other company factors.
- Medical, dental, and vision coverage.
- Life insurance.
- Disability insurance.
- 401(k) savings plan.
- Flexible spending accounts.
- Employee assistance program.
- Tuition reimbursement program.
- Voluntary group legal, critical illness, identity theft protection, pet insurance, and auto/home insurance benefits.
- Sick time policy, flexible vacation policy, and parental leave policy.
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
