Global Commercial Strategy (GCS): Senior Manager, Early GI, Rheumatology, and Neurology

Pfizer • New York City, NY

4d • Hybrid

About The Position

The Senior Manager, Early Commercial Rheumatology, GI, and Neurology is part of Pfizer’s Inflammation & Immunology (I&I) Early Commercial Business within Global Commercial Strategy and reports to the I&I Disease Area Lead. The role contributes to long-range commercial strategy, disease-area portfolio prioritization, early commercial assessments, and investment decision support across Rheumatology, GI, and Neurology. It helps translate portfolio ambitions into disease-area strategies, disciplined portfolio choices, and integrated commercial plans focused on patient impact and enterprise value.

The position serves as the asset-level commercial voice for assigned disease areas, applying scientific depth, commercial judgment, and an enterprise perspective to early development choices, product concepts, external innovation, and future value creation. The role works closely with R&D, Medical Affairs, Global Access Strategy & Pricing, Business Analytics & Insights, Competitive Intelligence, Business Development, and U.S. and international commercial teams. It requires working through ambiguity, influencing senior cross-functional stakeholders, advancing portfolio trade-offs and long-range planning, and supporting AI-enabled ways of working.

Responsibilities include supporting disease-area strategy and long-range planning; informing portfolio prioritization and investment decisions; leading early commercial assessments and product concept development; providing commercial input to external innovation and Business Development assessments; building cross-functional alignment and team capabilities; and promoting responsible AI-enabled approaches to portfolio strategy and decision support.

Requirements

• Bachelor’s degree required.
• At least 6 years of relevant experience with a BA/BS, 5 years with an MBA/MS, or 1 year with a PhD or JD in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, market research, forecasting, analytics, or a related field.
• Strong strategic and analytical skills, including the ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations.
• Experience leading early commercial assessments, business case development, opportunity assessments, or cross-functional strategic planning.
• Ability to engage in scientific and clinical dialogue and translate implications into commercial opportunity, differentiation, portfolio value, and enterprise decisions.
• Strong communication, executive presence, problem-solving, and stakeholder management skills.
• Ability to influence and collaborate with peers, develop and coach others, and oversee or guide colleagues’ work to achieve meaningful outcomes and business impact.
• Authorization to work in the United States; the position requires permanent U.S. work authorization, and U.S. work visa sponsorship is not available.

Nice To Haves

• MBA or other advanced degree.
• Advanced degree in business, life sciences, public health, medicine, pharmacy, or a related field.
• Experience in Rheumatology, GI, Neurology, I&I, specialty care, or other complex therapeutic areas.
• Experience in commercial development, early asset strategy, portfolio management, Business Development assessments, forecasting, valuation, or investment prioritization.
• Demonstrated ability to develop long-term product or disease-area strategies and secure senior leadership alignment.
• Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization.
• Track record of leading cross-functional teams, influencing without authority, and making recommendations with incomplete information.
• Comfort working in an AI-native or AI-augmented environment; experience using AI tools for strategy, synthesis, or analysis.
• Ability to thrive in ambiguity, maintain an enterprise mindset, and adapt to evolving portfolio priorities.
• Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters.

Responsibilities

• Support long-range commercial and portfolio strategy across assigned Rheumatology, GI, and Neurology disease areas, including pipeline assets, lifecycle opportunities, external innovation, and emerging opportunities.
• Develop integrated near-, mid-, and long-term views of disease-area opportunities, risks, and investment priorities.
• Synthesize scientific, clinical, commercial, access, competitive, and patient insights to identify opportunities and strategic trade-offs.
• Monitor scientific and competitive developments and assess their implications for I&I strategy.
• Translate disease-area strategy into recommendations and decision materials for leadership, governance forums, and portfolio discussions.
• Provide commercial leadership for portfolio prioritization, investment choices, and development opportunities in assigned disease areas.
• Pressure-test commercial assumptions, value drivers, risks, uncertainties, and evidence needs affecting launch potential, lifecycle value, and portfolio performance.
• Develop executive-ready materials that communicate strategic rationale, opportunity attractiveness, trade-offs, and recommended actions.
• Partner with cross-functional leaders on indication sequencing, evidence generation, market development, and lifecycle opportunities.
• Ground disease-area recommendations in patient need, scientific opportunity, market potential, access dynamics, and enterprise value.
• Lead early commercial assessments for pipeline assets, mechanisms, indications, disease-area opportunities, and potential product concepts.
• Develop and refine product concepts, target product profiles, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions.
• Translate unmet need, standard of care, competition, patient and HCP insights, and access considerations into differentiated commercial hypotheses.
• Provide commercial input to clinical development, evidence generation, lifecycle, and indication-sequencing discussions.
• Build repeatable approaches for high-quality early commercial strategy outputs.
• Lead commercial strategy input for external innovation and Business Development opportunities relevant to assigned disease areas.
• Assess strategic fit, market potential, valuation inputs, competitive scenarios, and portfolio implications for potential external opportunities.
• Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence to pressure-test assumptions and identify decision points.
• Represent the commercial perspective in discussions about external opportunities and disease-area strategy.
• Influence stakeholders without direct authority and build trusted cross-functional working relationships.
• Foster enterprise thinking, scientific curiosity, accountability, collaboration, and talent development within the team.
• Set expectations for responsible AI-enabled ways of working to improve the speed, quality, consistency, and scalability of portfolio strategy outputs.
• Champion AI-enabled tools for scientific and competitive landscape synthesis, market insight generation, scenario development, and decision-support efficiency.
• Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, and strategic decision-support processes.
• Use performance insights, stakeholder feedback, and team learnings to improve AI-enabled ways of working.

Benefits

• 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution
• Paid vacation, holidays, and personal days
• Paid caregiver, parental, and medical leave
• Medical, prescription drug, dental, and vision coverage
• Eligibility to participate in Pfizer’s Global Performance Plan with a 17.5% bonus target
• Eligibility to participate in a share-based long-term incentive program
• Relocation assistance may be available based on business needs and eligibility

What This Job Offers

• Job Type: Full-time
• Career Level: Senior