Senior Manager Digital Manufacturing & Shopfloor Innovation, CVRM

Genentech•Holly Springs, NC

11d•Onsite

About The Position

The Senior Manager of Digital Manufacturing & Shopfloor Innovation is the site’s operational and technical leader for transforming factory operations into a connected digital shopfloor. This hands-on people leadership role combines technical execution, program management, adoption leadership, and team development. The role leads implementation of digital technologies—including Digital Twin, paperless manufacturing, AR/VR, and connected worker systems—to empower operators, improve batch execution, and maximize plant performance. The position owns the site Digital Twin roadmap and architects the digital shopfloor experience, connecting operators with plant systems and real-time data. It bridges digital platforms and daily operations, ensuring operators have useful data visibility and insights for decision-making. The role also leads technology adoption across operational functions and manages a team of industrial engineers, operational excellence specialists, data specialists, and digital shopfloor technicians. The role is based at Roche/Genentech’s Holly Springs, North Carolina facility, a planned high-volume drug product manufacturing site focused on CVRM medicines, with a planned launch in 2028. Relocation assistance is available. The expected salary range is $133,400–$247,800, and a discretionary annual bonus may be available based on individual and Company performance.

Requirements

Bachelor of Science in Industrial Engineering, Electrical/Automation Engineering, Computer Science, Mechanical Engineering, or an equivalent technical field.
At least 8 years of experience in pharmaceutical manufacturing, smart factory initiatives, Manufacturing Execution Systems, or shopfloor digitization within pharmaceutical or biotech manufacturing.
Hands-on experience with Digital Twin architectures, simulation requirements, model validation, and generating operational insights.
Practical experience with enterprise AR/VR platforms, such as PTC Vuforia, HoloLens, or equivalent implementations.
Hands-on experience with eBR systems, electronic batch record workflows, and paperless manufacturing execution.
Familiarity with Industry 4.0 shopfloor connectivity protocols such as OPC UA and MQTT, and IoT edge device integration.
Deep understanding of pharmaceutical plant operations, including GMP, batch process control, and PAT, and integration of SCADA, MES, LIMS, and eBR systems.
Track record managing digital transformation programs, product roadmaps, and technology implementation initiatives.
Ability to translate complex operational requirements into prioritized use cases and technical specifications.
Experience identifying ROI opportunities and demonstrating value realization through operational metrics.
Demonstrated success driving technology adoption among diverse stakeholder groups, particularly operators and frontline personnel.
Experience with user-centered design and gathering and incorporating end-user feedback.
Ability to build grassroots support and overcome resistance to operational change.
Demonstrated cross-functional stakeholder management across technical teams, operations, engineering, quality, and learning and development.
Ability to lead, mentor, and develop high-performing technical teams.
Strong communication skills across organizational levels, from shopfloor operators to executive leadership.
Practical experience with Digital Twin platforms and simulation software such as AspenTech, Ansys, Siemens, or equivalent.
Experience with MES, eBR systems, SCADA, and shopfloor data collection systems.
Proficiency in documenting technical requirements and workflows.
Basic data literacy and ability to interpret operational metrics.

Nice To Haves

Lean Six Sigma Green or Black Belt certification.
Project Management Professional (PMP) certification.
Agile/Scrum Product Owner (CSPO/PSPO) certification.
Industry 4.0 or Smart Manufacturing certification.

Responsibilities

Own the site Digital Twin roadmap, demand, and backlog; translate business needs into requirements, KPIs, data needs, owners, and acceptance criteria.
Lead Digital Twin use cases from intake and prioritization through simulation development, validation, implementation, and benefit realization.
Coordinate internal and external inputs for Digital Twin models, validate model fidelity and accuracy, and manage user acceptance testing and business acceptance.
Manage the site budget for Digital Twin software enhancements, licenses, infrastructure upgrades, and vendor support.
Drive Digital Twin adoption through onboarding, training, a community of super-users, and communication of progress, risks, and ROI.
Design, validate, and roll out paperless shopfloor technologies integrated with manufacturing execution and enterprise resource planning systems.
Validate paperless workflows for accuracy, usability, and GMP compliance; oversee electronic logbooks, mobile operator applications, and digital task management systems.
Define and execute the Connected Worker Strategy, identifying and deploying edge devices, wearables, and interactive shopfloor stations.
Ensure paperless solutions meet data integrity, traceability, FDA 21 CFR Part 11, and ALCOA+ requirements.
Lead evaluation and deployment of AR/VR systems for operator training, line changeovers, remote expert assistance, equipment troubleshooting, and other shopfloor use cases.
Test AR/VR implementations on the shopfloor and partner with Learning & Development to incorporate them into operator qualification and training.
Drive technology adoption using user-centered design, operator feedback, change enablement, adoption roadmaps, and continuous feedback mechanisms.
Design an integrated digital shopfloor ecosystem connecting operators, SCADA, MES, LIMS, Digital Twin, eBR, and real-time data.
Collaborate with IT/OT and Manufacturing Systems teams on shopfloor connectivity, edge device integration, and data flow to operator interfaces.
Define data requirements and ensure operators have access to real-time plant status, batch progress, equipment health, and Digital Twin recommendations.
Establish KPIs to measure business and operator value, report metrics and ROI, and identify further manufacturing use cases and improvement projects.
Build, mentor, and lead a high-performing team of Industrial Engineers, operational excellence specialists, data specialists, and digital shopfloor technicians.
Foster innovation, technical excellence, and operator-centric thinking; provide technical mentoring and develop team members’ capabilities.