Senior Manager Digital Manufacturing & Shopfloor Innovation, CVRM

Roche•Holly Springs, NC

9h•$133,400 - $247,800•Onsite

About The Position

The Senior Manager of Digital Manufacturing & Shopfloor Innovation is the site's operational and technical leader responsible for transforming physical factory operations into a connected digital shopfloor. This hands-on people leadership role combines technical execution, program management, adoption leadership, and team development. The role leads the implementation of digital technologies—including a Digital Twin framework, paperless manufacturing solutions, immersive technologies (AR/VR), and connected worker systems—to empower plant operators, improve batch execution, and maximize plant performance. The role owns the site Digital Twin roadmap and demand backlog, leading use cases from intake and prioritization through development, validation, implementation, and benefit realization. It also architects the digital shopfloor experience by ensuring operators have real-time data visibility and connectivity to plant systems. The position leads paperless manufacturing and connected-worker strategies, evaluates and deploys AR/VR technologies, guides change management and adoption, and oversees shopfloor integration and value tracking. It builds and develops a high-performing team and works across Operations, Engineering, Quality, Warehouse, IT/Data, and Learning & Development. The position is based at Genentech's Holly Springs, North Carolina facility, a planned high-volume drug product manufacturing site with a planned launch in 2028. Relocation assistance is available. The expected salary range for the primary location is $133,400–$247,800. A discretionary annual bonus may be available based on individual and company performance.

Requirements

Bachelor of Science in Industrial Engineering, Electrical/Automation Engineering, Computer Science, Mechanical Engineering, or an equivalent technical field.
At least 8 years of experience in pharmaceutical manufacturing, smart factory initiatives, Manufacturing Execution Systems, or shopfloor digitization within pharmaceutical or biotech manufacturing.
Hands-on experience with Digital Twin architectures, including understanding simulation requirements, validating model accuracy, and deriving operational insights.
Practical experience with enterprise AR/VR platforms, such as PTC Vuforia, HoloLens, or equivalent implementations.
Hands-on experience with electronic batch record systems, electronic batch record workflows, and paperless manufacturing execution.
Familiarity with Industry 4.0 shopfloor connectivity protocols such as OPC UA and MQTT, and IoT edge device integration.
Deep understanding of pharmaceutical plant operations, including GMP, batch process control, and PAT, as well as integration of SCADA, MES, LIMS, and eBR systems.
Experience managing digital transformation programs, product roadmaps, and technology implementation initiatives.
Ability to translate operational requirements into prioritized use cases and technical specifications.
Background identifying return-on-investment opportunities and demonstrating value through operational metrics.
Success driving technology adoption across stakeholders, particularly operators and frontline personnel, and incorporating user feedback into solutions.
Ability to build grassroots support and overcome resistance to operational change.
Cross-functional stakeholder management skills, including bridging technical teams, Operations, Engineering, Quality, and Learning & Development.
Ability to lead, mentor, and develop technical teams and communicate with audiences from shopfloor operators to executive leadership.
Practical experience with Digital Twin platforms and simulation software such as AspenTech, Ansys, Siemens, or equivalent.
Experience with MES, eBR systems, SCADA, and shopfloor data collection systems; proficiency documenting technical requirements and workflows; and basic data literacy to interpret operational metrics.

Nice To Haves

Lean Six Sigma Green Belt or Black Belt certification.
Project Management Professional (PMP) certification.
Agile/Scrum Product Owner certification (CSPO/PSPO).
Industry 4.0 or Smart Manufacturing certification.

Responsibilities

Own the site Digital Twin roadmap and backlog, translating business needs into use cases with defined owners, KPIs, data requirements, and acceptance criteria.
Lead Digital Twin use cases from intake and prioritization through simulation development, validation, implementation, and benefit realization.
Coordinate process data, layouts, equipment information, automation logic, and 3D/BIM inputs with internal teams and external partners.
Work with third-party simulation experts on model development and enhancement, and validate simulations for fidelity and accuracy against real-world plant conditions.
Coordinate user acceptance testing, model validation, and business acceptance with Operations, Engineering, Quality, Warehouse, and IT/Data subject matter experts.
Manage the site budget for Digital Twin software enhancements, licenses, infrastructure upgrades, and vendor support.
Drive Digital Twin adoption, user onboarding, and training, particularly for operators and supervisors; lead a community of super-users and serve as the site interface to the Global Digital Twin Product Owner.
Communicate Digital Twin progress, risks, and return on investment to executives, peer managers, and shopfloor teams.
Lead the design, validation, and rollout of paperless shopfloor technologies integrated with manufacturing execution and enterprise resource planning systems.
Validate paperless workflows for accuracy, usability, and GMP compliance; oversee electronic logbooks, mobile operator applications, and digital task management systems.
Define and execute the Connected Worker Strategy, deploying edge devices, wearables, and interactive shopfloor stations for access to plant data, Digital Twin insights, and guidance.
Ensure paperless solutions maintain data integrity, traceability, and GMP compliance aligned with FDA 21 CFR Part 11 and ALCOA+ principles.
Lead the strategy, evaluation, testing, and deployment of AR/VR systems for operator training, line changeovers, remote expert assistance, equipment troubleshooting, and other suitable use cases.
Partner with Learning & Development to integrate immersive applications into operator qualification and ongoing training programs.
Drive shopfloor technology adoption through user-centered design, operator feedback, change enablement, and rollout roadmaps aligned with operational priorities.
Build relationships with Plant Operations leadership, shift supervisors, and operators; establish forums and feedback mechanisms to capture operator insights and improve digital solutions.
Design the integrated digital shopfloor ecosystem connecting operators with SCADA, MES, LIMS, Digital Twin, eBR, and real-time data.
Collaborate with IT/OT and Manufacturing Systems teams on shopfloor connectivity, edge device integration, and data flow to operator interfaces.
Define data requirements and ensure operators can access real-time information on plant status, batch progress, equipment health, and Digital Twin recommendations.
Establish and report KPIs and ROI for digital shopfloor initiatives, and identify further manufacturing use cases and continuous improvement opportunities.
Build, mentor, and lead a high-performing team of Industrial Engineers, operational excellence specialists, data specialists, and digital shopfloor technicians.
Foster innovation, technical excellence, and operator-centric thinking, while mentoring team members and developing their technical and leadership capabilities.