Senior Director, Physician Scientist – Immunology & Translational Medicine

CSL

3d•$338,000 - $400,000•Hybrid

About The Position

CSL Behring is a global biopharmaceutical leader committed to developing innovative therapies for patients with rare and serious diseases. The Immunology franchise is advancing a diverse pipeline targeting autoimmune and inflammatory conditions across rheumatology, neuroimmunology, and rare dermatology. This is a hybrid position, requiring three days onsite per week, and you will report to the Research Therapeutic Area Lead, Immunology/Transplant and Vaccines. You will work hands-on as a clinical subject matter expert embedded with the research team, bringing a true bench-to-bedside mindset rather than a purely advisory role. Partnering day-to-day with the Research Therapeutic Area Lead and bench scientists, you will roll up your sleeves to prioritize therapeutic targets, shape clinical development plans, and directly translate mechanistic and preclinical data into first-in-class or best-in-class immunology therapies. You will be an active, present partner from early ideation through first-in-disease, working shoulder-to-shoulder with discovery research, translational medicine, clinical development, and business development to advance CSL Behring's immunology pipeline. This is a high-impact role directly influencing portfolio prioritization, target assessment, and early clinical program design through active day-to-day collaboration, not just strategic oversight.

Requirements

MD or DO with clinical experience in rheumatology (preferred); neuroimmunology and/or dermatology also acceptable
Demonstrated bench-to-bedside research mindset with hands-on, working-level experience translating preclinical and translational science into clinical strategy, not purely oversight experience
Experience in drug development within a biotech, pharmaceutical, or academic environment
Demonstrated hands-on experience in preclinical to first-in-disease (or equivalent early clinical milestone) programs in immunology
Deep scientific expertise in the immunological mechanisms underpinning autoimmune and inflammatory diseases
Established and active network in drug development with recognized relationships across rheumatology, neuroimmunology, and/or dermatology communities
Proven track record of evaluation of preclinical and clinical assets, including direct target assessment, data package review, and go/no-go decision-making, plus active support of BD due diligence and TPP drafting
Strong ability to synthesize complex scientific data and communicate strategy clearly to diverse audiences including senior leadership

Responsibilities

Act as the hands-on clinical subject matter expert and internal champion for one or more immunology disease areas, with rheumatology expertise strongly preferred; neuroimmunology and/or dermatology also considered
Bring a bench-to-bedside mindset, working directly with bench scientists to translate mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies
Sit alongside the research team as an active partner in prioritizing therapeutic targets and building out clinical development plans, not just reviewing decisions after the fact
Stay personally close to the competitive landscape, emerging science, and unmet medical need across assigned disease areas, digging into primary data and literature directly
Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and actively maintain a hands-on network of thought leaders, clinical investigators, and academic collaborators
Get directly involved end-to-end in asset progression from ideation through first-in-disease designation, personally working through scientific rationale, translational endpoints, patient population selection, and clinical strategy alongside the project team
Lead or co-lead target and asset evaluation activities, personally reviewing preclinical and clinical data packages, mechanism-of-action assessments, and translational feasibility analyses line by line
Partner with development colleagues on IND-enabling studies, proof-of-concept study designs, and Phase 1/1b protocol development, working directly with study teams
Be the go-to immunology clinical subject matter expert embedded with discovery colleagues day-to-day, bridging preclinical science and clinical relevance to directly shape program design and go/no-go decisions
Work hands-on with discovery and translational teams to define disease-relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs
Actively contribute to R&D programs as a working subject matter expert, providing direct, in-the-weeds guidance on the clinical development pathway
Partner closely and continuously with the Research Therapeutic Area Lead, RPLs, and Immunology core team members to prioritize therapeutic targets and personally help maintain a best-in-class immunology portfolio
Partner directly with Business Development colleagues on in-licensing, and partnering opportunities within immunology, on clinical and scientific due diligence
Contribute to drafting Target Product Profiles (TPPs), integrated development plans, and portfolio reviews in partnership with clinical, commercial, and research colleagues
Provide disease area expertise to regulatory submissions, clinical study reports, and scientific communications