Scientist 3 - Translational Medicine
About The Position
Genentech’s Translational Medicine OMNI team supports research and development of novel therapies across Ophthalmology, Metabolism, Neuroscience, Immunology, and Infectious Diseases. The team develops translational research and biomarker strategies to investigate disease pathways, validate mechanisms of action, and support clinical trials. The Scientist 3 will join the Translational Medicine team on-site at Genentech’s South San Francisco campus. The role partners with cross-functional R&D teams on translational research for emerging therapeutic targets and provides biomarker support for glaucoma neuroprotection programs throughout drug development. It bridges computational analysis of high-dimensional datasets with hands-on laboratory work to validate findings and advance foundational research in ophthalmic drug development. The position involves analyzing clinical and preclinical datasets, conducting experiments in disease-relevant human cell models, coordinating exploratory clinical studies, and developing custom biomarker assays. The scientist will collaborate with internal and external partners and communicate findings through reports, presentations, and peer-reviewed publications.
Requirements
- PhD in Biological Sciences, such as neuroscience, immunology, cell biology, or a related field, with 0–4 years of relevant post-graduate experience; candidates without a PhD may apply if they have an equivalent track record of rigorous scientific experience.
- Track record of conducting both wet-lab experiments and bioinformatic analyses to address complex biological questions, demonstrated by a strong peer-reviewed publication record.
- Deep wet-lab expertise in preclinical or clinical sample analysis and molecular biology techniques, including cell culture, ELISA, qPCR, and NGS/transcriptomics.
- Computational proficiency, including hands-on programming experience in R or Python and application of biostatistical and bioinformatics methods to high-dimensional datasets.
- Scientific independence, strong organizational and teamwork skills, scientific curiosity, and exceptional communication abilities.
- Clear interest in translating science into therapies.
Nice To Haves
- Clinical or translational experience in retinal biology is preferred but not required.
Responsibilities
- Analyze high-dimensional datasets, including proteomics and transcriptomics from clinical and preclinical samples, to identify therapeutic targets and candidate biomarkers.
- Design and conduct experiments using disease-relevant in vitro human cell models to investigate data-driven biological insights.
- Lead and coordinate exploratory clinical studies with internal and external collaborators to advance translational research and identify clinical biomarkers.
- Collaborate with R&D partners in Research Biology, Computational Sciences, Tissue Genomics & Proteomics, Biostatistics, Clinical Pharmacology, and Bioanalytical Sciences.
- Develop and qualify custom assays, such as Simoa and NULISA, for biomarkers of interest and pipeline programs.
- Communicate scientific findings through reports, presentations, and peer-reviewed publications.
Benefits
- A discretionary annual bonus may be available based on individual and company performance.
- The position qualifies for company benefits detailed at the link provided in the posting.
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What This Job Offers
Job Type
Full-time
Career Level
Entry Level
Education Level
Ph.D. or professional degree
