Principal Scientist/Associate Director, Translational Medicine

GondolaBio Service Co • Boston, MA

1d

About The Position

GondolaBio is a clinical-stage biopharmaceutical company developing therapeutics for genetic diseases. This role partners with the Translational Medicine VP to drive clinical biomarker strategy and execution across early neuroscience clinical programs. The position translates discovery-stage hypotheses and preclinical findings into clinically actionable biomarker approaches, ensuring assays are fit for purpose, validated, and operationally feasible in global studies. The work informs measurement of target engagement, pharmacodynamic effects, and disease biology in patients.

The scientist works across discovery, preclinical, clinical development, clinical operations, regulatory, and data science teams. Responsibilities include leading biomarker assay development and validation, coordinating execution with CROs and external laboratories, and integrating biomarker findings with clinical, PK/PD, and safety data to support decisions. The role also contributes to protocol design, regulatory documentation, sample collection planning, and study logistics.

GondolaBio describes its work environment as collaborative, fast-paced, and data-driven, emphasizing patient impact, scientific rigor, ownership, and learning and development. The position offers a base pay range of $190,000–$210,000 per year, with compensation determined by job-related factors, and a robust, market-competitive compensation and benefits package.

Requirements

• PhD or equivalent in a relevant discipline.
• 8+ years of experience in translational medicine, biomarker sciences, or clinical bioanalysis.
• Experience managing biomarker strategies in global clinical studies and working with CROs.
• Understanding of biomarker assay platforms and bioanalytical validation principles.
• Experience working in or with CLIA or regulated laboratory environments.

Nice To Haves

• Experience in neurology or CNS disorders.
• Experience with intrathecal or CNS-targeted therapeutics.
• Familiarity with CSF biomarker workflows or neurophysiological biomarkers such as EEG.
• Experience contributing to regulatory submissions.

Responsibilities

• Partner with discovery and preclinical teams to identify and prioritize translational biomarkers.
• Translate preclinical findings into clinical biomarker strategies, including pharmacodynamic, target engagement, and disease-relevant endpoints.
• Lead development, qualification, and validation of biomarker assays.
• Oversee assay transfer, validation, and execution at CROs and external laboratories.
• Ensure assays are implemented in CLIA-compliant or equivalent environments when appropriate.
• Partner with Clinical Operations to design sample collection schedules, lab manuals, and logistics workflows.
• Coordinate with clinical sites and vendors to ensure sample integrity and operational feasibility.
• Integrate biomarker data with clinical, PK/PD, and safety datasets to generate decision-ready insights.
• Contribute to clinical protocol design, regulatory documentation, and cross-functional decision-making.
• Serve as a key partner across discovery, clinical development, clinical operations, regulatory, and data science teams.

Benefits

• Patient Days to hear directly from people living with the conditions GondolaBio aims to address.
• Access to learning and development resources.
• Robust, market-competitive compensation and benefits package, including base pay, performance bonus, equity, and health, welfare, and retirement programs.
• Flexible PTO.
• Potential to work on multiple GondolaBio programs across multiple therapeutic areas over time.
• Partnerships with leading institutions.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: Ph.D. or professional degree