Senior Associate Scientist, LC/LC-MS

Bristol Myers Squibb • Cambridge, MA

1d • $96,010 - $116,339 • Hybrid

About The Position

BMS at Kendall Square is seeking a highly skilled and motivated Senior Associate Scientist with strong expertise in analytical method development to support the advancement of novel RNA therapeutics. The successful candidate will leverage liquid chromatography and LC/MS technologies to design, develop, and execute analytical methods that enable comprehensive characterization of lipids, antibodies, and RNA-based modalities across discovery and development stages. This role will play a critical part in generating high-quality analytical data to support product understanding, process development, and CMC strategies.

Requirements

• B.S./M.S. in Analytical Chemistry, Biochemistry, or a related discipline with 2+ years of relevant CMC-related experience; PhD. candidates with the appropriate experience will be considered.
• Experience with LC-MS method development, impurity characterization, and structural elucidation using high-resolution MS platforms.
• Experience with LNP drug products, antibodies, and RNA/oligonucleotide analysis preferred.
• Ability to manage multiple projects and priorities in a fast-paced environment
• Strong technical writing skills for reports, protocols, and regulatory documentation
• Familiarity with regulatory expectations (e.g., ICH, FDA) for analytical data and submissions

Responsibilities

• Independently design, develop, and optimize analytical methods to characterize RNA-based therapeutics, lipid nanoparticles, and related components using advanced LC and LC/MS platforms.
• Lead phase-appropriate method lifecycle activities, including method development, qualification, validation, and transfer to internal and external laboratories (e.g., CROs/CDMOs), with authorship of SOPs, protocols, and technical reports.
• Collaborate cross-functionally with process development, formulation, research, and manufacturing teams to support analytical development, troubleshoot issues, and enable program milestones and timelines.
• Troubleshoot complex analytical challenges, interpret data, and provide scientifically sound recommendations to resolve issues and improve assay performance and robustness.
• Perform and oversee routine and non-routine analytical testing, including data review, verification, and interpretation to ensure data quality, integrity, and compliance with internal standards.
• Operate, maintain, and troubleshoot LC and MS instrumentation.
• Analyze and communicate complex analytical data, generating clear, concise reports and presentations to inform technical teams and leadership decisions.

Benefits

• Health Coverage: Medical, pharmacy, dental, and vision care.
• Wellbeing Support: Programs such as BMS Well-Being Account, BMS Living Life Better, and Employee Assistance Programs (EAP).
• Financial Well-being and Protection: 401(k) plan, short- and long-term disability, life insurance, accident insurance, supplemental health insurance, business travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.
• Work-life benefits include: Paid Time Off US Exempt Employees: flexible time off (unlimited, with manager approval, 11 paid national holidays (not applicable to employees in Phoenix, AZ, Puerto Rico or Rayzebio employees) Phoenix, AZ, Puerto Rico and Rayzebio Exempt, Non-Exempt, Hourly Employees: 160 hours annual paid vacation for new hires with manager approval, 11 national holidays, and 3 optional holidays
• Based on eligibility, additional time off for employees may include unlimited paid sick time, up to 2 paid volunteer days per year, summer hours flexibility, leaves of absence for medical, personal, parental, caregiver, bereavement, and military needs and an annual Global Shutdown between Christmas and New Years Day.
• All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior