Scientist I LC/MS - Bioanalytical

BioAgilytix•San Diego, CA

1d•$88,000 - $99,000•Onsite

About The Position

In this lab-based, hands-on Scientist role, you will design, develop, and execute bioanalytical experiments that support the advancement of new therapies to market. You’ll spend much of your time in the lab generating and analyzing data, working with cutting-edge bioanalytical technologies, and evaluating assay performance within the intended context of use. This role is especially exciting due to our wide variety of clients and therapeutic areas, giving you exposure to multiple disease states and modalities. You’ll work in a milestone-driven, highly regulated environment where data integrity, quality, and compliance are foundational to how we operate. We’re looking for scientists who are energized by hands-on laboratory work and solving complex scientific challenges. The ideal candidate is curious, driven to continuously learn, and experienced working under GxP expectations where data integrity is expected and upheld. You’ll thrive through collaboration with a network of expert scientists while managing multiple projects, sponsors, and timelines. If you’re adaptable, scientifically rigorous, and motivated by producing high-quality data at the bench, you’ll feel right at home at BioAgilytix.

Requirements

Ability to perform routine laboratory tasks accurately while following established methodologies, including sample preparation, operation and maintenance of standard laboratory equipment.
Experience with chromatographic assay development, validation, and execution for PK, PD (biomarker), ADME, and other small molecule assays.
Experience developing chromatographic assays using LC-MS/MS, HPLC, UPLC, and/or UPLC-HRMS, including protein binding, CYP inhibition, CYP induction, or CYP phenotyping assays.
Strong data analysis, statistical analysis, and data visualization skills.
Proficiency with Microsoft Office (Word, Excel) and scientific software such as Sciex OS/Analyst, MassLynx, Chromeleon, Watson LIMS, JMP, and GraphPad Prism.
Experience working in a regulated laboratory environment with knowledge of GxP principles, including GLP, GCLP, GCP, and Good Documentation Practices (GDP).
Strong experimental design, troubleshooting, and scientific problem-solving skills.
Ability to manage multiple priorities, work independently, and adapt to changing priorities while taking direction effectively.
Highly organized, detail-oriented, and able to meet deadlines in a fast-paced environment.
Strong verbal and written communication skills with the ability to collaborate effectively across cross-functional teams.
Demonstrated customer service mindset with a commitment to delivering high-quality results for internal and external stakeholders.
Bachelor’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than six (6) years’ experience in a scientific laboratory environment; or Master’s degree in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than four (4) years’ experience in a scientific laboratory environment; or PhD in chemistry, biochemistry, biotechnology, biology, immunology, or related field with not less than two (2) years’ experience in a scientific laboratory environment

Nice To Haves

Knowledge of regulatory guidance and industry best practices for PK, ADME, LC/MC/MC, and other small molecule assays is preferred

Responsibilities

Lead the development, validation, and sample analysis of large molecules such as ADCs, monoclonal antibodies and other proteins, peptides, oligonucleotides, biomarkers, and small molecules using various techniques including chromatographic (LC-MS/MS) in support of preclinical and clinical PK/PD studies.
Plan and direct experimental design for junior staff
Drive bioanalytical projects to align with client timelines
Frequent communication with clients to discuss technical details and provide project updates.
Advise clients on PK/ADME assay best practices
Author documents (methods, SOPs, reports)
Statistical analysis of bioanalytical data
Review of documentation
Peer review raw data
Prepare reagents
Troubleshoot assays
Design assay runs independently
Responsible for prompt identification and notification of deviations
Write plans/reports for sample analysis
Order and keep accurate inventories of supplies for laboratory needs and forecast future needs based on projected project needs
Perform assays according to GLP guidance or SOPs
Other duties as needed