Scientist - LC-MS/MS Bioanalytical

Amgen • Thousand Oaks, CA

1d • $109,020 - $147,498 • Onsite

About The Position

Join Amgen’s Mission of Serving Patients. At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Requirements

• Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable] OR Master’s degree and 3 years of LC-MS/MS Bioanalytical experience OR Bachelor’s degree and 5 years of LC-MS/MS Bioanalytical experience
• Must be willing to work in a fast-paced, multi-project environment with high workload demands, and consistently deliver high-quality results within established timelines.
• Demonstrated ability to efficiently resolve scientific challenges, prioritize and effectively manage multiple projects.
• Excellent scientific problem-solving skills.
• Excellent project and time management abilities.
• Ability to work collaboratively with internal and external stakeholders.

Nice To Haves

• Familiarity with peptide and protein quantitation by hybrid LC-MS/MS methodology and affinity capture techniques a plus.
• Prior experience in pharma/biotech strongly desired.
• Strong technical expertise in quantitative mass spectrometry on triple quadrupole (QQQ) platforms.
• Demonstrated expertise in working with a variety of sample types (e.g., blood, plasma, tissues, urine, cerebrospinal fluid) employing diverse sample preparation techniques (e.g., SPE, LLE) to support analysis of small molecules and metabolites by LC-MS/MS.
• Experience with an array of analytical equipment and technologies that can accelerate bioanalysis including automation and/or micro-sampling.
• Prior GLP and GCP experience.
• Prior experience in bioanalytical (regulated) assay execution and method transfer to external contract laboratories.
• Understanding of pharmacokinetic and toxicokinetic principles and analysis.
• Supervisory and mentoring experience in a lab-based setting.

Responsibilities

• Independently support the design, development, validation, and implementation of robust quantitative LC-MS/MS bioanalytical methods and experiments for small molecules and perform bioanalysis for discovery, GLP preclinical and regulated clinical studies.
• Critically review and interpret scientific data and results.
• Report generation.
• Project management.
• Communication of results.
• Data presentations.
• Supporting automation efforts.
• Keeping current with technology development.
• Involve multidisciplinary collaborations with scientists across research and development at Amgen.
• May include contribution to key/critical teams and participation in national scientific meetings.
• Provide scientific results that may support the generation of publications, patents or regulatory submissions.
• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times.
• Conduct small molecule bioanalysis of parent and metabolites in non-clinical and clinical samples from various matrices (plasma, urine, CSF, tissues).
• Perform biological sample extraction using protein precipitation, SPE, and LLE.
• Generate complete, accurate, and concise documentation using LIMS and electronic laboratory notebook systems.
• Ensure bioanalytical data meets regulatory expectations for global submissions by maintaining accurate records and staying current with industry guidelines.
• Author study reports, standard operating procedures, analytical methods, memos, scientific publications, and other regulatory compliant documents.
• Communicate bioanalytical data to key discovery and development teams, contribute to scientific publications, and present at professional meetings.
• Comply with safety guidelines and site-specific procedures which include but are not limited to the completion of training on assigned tasks, maintenance of training records, laboratory documentation, and following detailed SOPs and other written procedures.
• Perform general laboratory housekeeping activities and operational support as needed.

Benefits

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior