Senior Analog/Mixed-Signal Hardware Engineer, Single-Molecule Sensing Instrumentation

Flagship Pioneering•Cambridge, MA

About The Position

Tilde Bio, Inc. (FL110), a Flagship Pioneering company, is building a next-generation biological sensing platform combining synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. The platform aims to extract rich molecular information from single-molecule interactions using programmable biological measurement systems. The Senior Electrical Engineer will own electronics that enable nanopore measurements, from the analog front end through the board-level system. The role focuses on low-noise analog and mixed-signal design and PCB design and development for complex instrumentation supporting the biological sensing platform. The engineer will design, lay out, integrate, and validate complex PCBs, working closely with firmware, mechanical, bioengineering, systems, software, hardware, and external vendor teams to deliver robust, manufacturable, high-performance hardware from concept through production. The role reports to the VP of Technology and Development. The team includes four engineers plus consultants. The product is in a full-product-cycle stage, beginning with prototyping, and the first-year focus is prototyping sensors.

Requirements

B.S., M.S., or Ph.D. in Electrical Engineering or a related field.
At least 5 years of industry experience in PCB design and hardware development.
Demonstrated expertise in multilayer PCB design for low-noise analog and mixed-signal systems.
Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
Hands-on experience with board bring-up, debugging, and laboratory instrumentation, including oscilloscopes, logic analyzers, and spectrum analyzers.
Experience taking products from prototype through manufacturing.

Nice To Haves

Experience with low-noise electrophysiology, patch-clamp, or nanopore instrumentation.
Experience with high-speed interfaces such as USB, Ethernet, PCIe, DDR, SPI, or I2C.
Experience designing electronics for scientific instrumentation, medical devices, or life sciences platforms.
Familiarity with FPGA-based systems and embedded processors.
Experience with high-density interconnect (HDI) design and fine-pitch components.
Knowledge of regulatory compliance standards such as CE, FCC, or IEC.
Experience working in early-stage or startup environments.

Responsibilities

Lead the design and development of complex multilayer PCBs for advanced instrumentation systems, including low-noise, picoamp-level sensing electronics.
Architect low-noise mixed-signal circuit designs, including analog front ends, power management, data acquisition, and embedded processing systems.
Collaborate with software and hardware engineers and external vendors to support hardware–software integration and instrument development.
Develop and maintain documentation, including schematics, layout files, validation reports, and specifications.
Drive design reviews and apply design for manufacturability (DFM) and design for testability (DFT) best practices.
Contribute to intellectual property generation and technical strategy discussions.
Design, integrate, and validate PCB and board-level systems from concept through production.