Senior Analog/Mixed-Signal Hardware Engineer, Single-Molecule Sensing Instrumentation
About The Position
Tilde Bio, Inc. (FL110), a Flagship Pioneering company, is building a next-generation biological sensing platform combining synthetic biology, protein engineering, nanopore biophysics, electrophysiology, signal processing, and machine learning. The company aims to develop programmable biological measurement systems that extract molecular information from single-molecule interactions. The Senior Analog/Mixed-Signal Hardware Engineer will own electronics that enable nanopore measurements, from the analog front end through the board-level system. The role focuses on low-noise analog and mixed-signal design and PCB design and development for complex instrumentation supporting the biological sensing platform. The engineer will collaborate with firmware, software, mechanical, bioengineering, systems, and external vendor teams to deliver robust, manufacturable, high-performance hardware from concept through production. The first-year focus is prototyping sensors. The position reports to the VP of Technology and Development and works with a team of four engineers plus consultants.
Requirements
- Bachelor’s, master’s, or Ph.D. in Electrical Engineering or a related field.
- At least 5 years of industry experience in PCB design and hardware development.
- Demonstrated expertise in multilayer PCB design for low-noise analog and mixed-signal systems.
- Deep understanding of signal integrity, power integrity, grounding strategies, and EMI/EMC mitigation.
- Hands-on experience with board bring-up, debugging, and laboratory instrumentation such as oscilloscopes, logic analyzers, and spectrum analyzers.
- Experience taking products from prototype through manufacturing.
Nice To Haves
- Experience with low-noise electrophysiology, patch-clamp, or nanopore instrumentation.
- Experience with high-speed interfaces such as USB, Ethernet, PCIe, DDR, SPI, or I2C.
- Experience designing electronics for scientific instrumentation, medical devices, or life sciences platforms.
- Familiarity with FPGA-based systems and embedded processors.
- Experience with high-density interconnect (HDI) design and fine-pitch components.
- Knowledge of regulatory compliance standards such as CE, FCC, or IEC.
- Experience working in early-stage or startup environments.
Responsibilities
- Lead the design and development of complex, multilayer PCBs for advanced instrumentation systems, including low-noise, picoamp-level sensing electronics.
- Architect low-noise mixed-signal circuit designs, including analog front ends, power management, data acquisition, and embedded processing systems.
- Collaborate with software and hardware engineers and external vendors to support hardware-software integration and instrument development.
- Develop and maintain schematics, layout files, validation reports, specifications, and other comprehensive documentation.
- Drive design reviews and apply design-for-manufacturability (DFM) and design-for-testability (DFT) best practices.
- Contribute to intellectual property generation and technical strategy discussions.
- Design, integrate, and validate complex PCBs supporting the biological sensing platform.
Benefits
- Healthcare coverage
- Annual incentive program
- Retirement benefits
- A broad range of other benefits
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What This Job Offers
Job Type
Full-time
Career Level
Senior
