Scientist/Sr. Scientist, Molecular Technology Development, Hsu & Konermann Lab

The Scientist or Senior Scientist position at the Arc Institute in Palo Alto, CA, focuses on Molecular Technology Development, Genome Engineering, and Synthetic Biology. The role involves working on projects related to genome, transcriptome, and epigenome engineering tools, as well as synthetic biology and machine learning applications. The successful candidate will be part of a fully funded team, collaborating closely with the Principal Investigators to invent, develop, and benchmark molecular technologies. This position offers the opportunity to address unanswered scientific questions and contribute to advancements in neurodegeneration, gene and cell therapy, and more.

• Work as part of a fully funded team to invent, develop, and benchmark molecular technologies.
• Collaborate closely with the PIs on planning and executing scientific research.
• Contribute to early-stage discovery and development of new genome, transcriptome, and epigenome engineering tools in mammalian cells.
• Contribute to the development of parts, sensors, and concepts for synthetic biology.
• Apply machine learning and protein language models to accelerate molecular technology parameters.
• Conduct research in the areas of Molecular Technology Development, Genome Engineering, and Synthetic Biology.
• Use DNA and RNA-targeting CRISPR systems, single-cell genomics, and high-throughput methods for protein engineering.
• Tackle big questions in neurodegeneration, synthetic biology, gene & cell therapy, and beyond.
• Collaborate with people of different backgrounds and brainstorm ideas on addressing scientific questions.
• Optimize research processes to ensure efficiency and effectiveness.

• Scientist or Senior Scientist position
• Based at the Arc Institute in Palo Alto, CA
• Working in the areas of Molecular Technology Development, Genome Engineering, and Synthetic Biology
• Experience with DNA and RNA-targeting CRISPR systems, single-cell genomics, and high-throughput methods for protein engineering
• Familiarity with genome, transcriptome, and epigenome engineering tools in mammalian cells
• Knowledge of synthetic biology, including engineering cell states, controlling or tracing cellular communication, and developing therapeutic circuits
• Proficiency in machine learning and protein language models for molecular technology parameters
• Driven by science and purpose
• Strong collaboration skills
• Curiosity and ability to ask new questions
• Optimization mindset for efficient and effective research

• Fully funded research groups
• Development and deployment of advanced experimental and computational technologies
• First-class support operationally, financially, and scientifically
• Focused on scientific curiosity, commitment to truth, broad ambition, and selfless collaboration
• State-of-the-art lab facility
• Opportunity to work on early-stage discovery and development of new genome, transcriptome, and epigenome engineering tools
• Collaboration with PIs on scientific research projects
• Leadership opportunities and mentoring of students and research assistants
• Keeping up-to-date on advances in the field through literature reading and conference attendance
• Training and development opportunities for lab personnel
• Assistance with manuscript, abstract, and presentation preparation
• Competitive base salary range
• Eligibility for annual discretionary bonus