Scientist II, In Vivo Pharmacology
About The Position
Our expanding In Vivo Tumor Biology group in Lake County, IL is hiring a motivated tumor biologist dedicated to discovering and developing innovative small-molecule and biologic therapeutics. The position will focus on tumor-targeting biologics including ADCs and T-cell engager (TCE) therapeutics in both immunocompromised and humanized mouse models. Our scientists collaborate with in vitro biology, translational/biomarker, and medicinal chemistry teams to advance oncology agents through the R&D pipeline. The position is within a dynamic, collaborative research team passionate about advancing novel science and improving patients' lives. The successful candidate will have expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice. Excellent communication skills and a willingness to work with a multidisciplinary team of researchers are essential. Strong candidates have experience in ADC and TCE therapeutics and familiarity with humanized mouse studies.
Requirements
- BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
- Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
- Demonstrated ability to learn, understand and master new experimental techniques.
- Ability to multitask and work within timelines.
- Demonstrated scientific writing skills and strong verbal communication skills.
Nice To Haves
- Expertise in designing and executing studies using tumor models in both immunocompromised and immunocompetent mice.
- Experience in ADC and TCE therapeutics
- Familiarity with humanized mouse studies.
Responsibilities
- Independently execute, monitor, and interpret in vivo mouse cancer studies (e.g. CDX, PDX, disseminated, syngeneic)
- Evaluate novel cancer therapeutics in vivo through efficacy, PK, and tolerability studies.
- Collect and prepare tissue from in vivo tumor studies for PD analysis in downstream applications, including IHC, flow cytometry, and RNAseq
- Identify, validate and utilize humanized mouse models to support Abbvie pipeline assets.
- Interpret results and draw conclusions from own multistage experiments and suggest, design, and pursue relevant experiments that further project goals.
- Perform routine and complex tasks competently and independently. May innovate new experimental protocols/techniques.
- Appetite for developing novel in vivo approaches and models to address complex biological questions.
Benefits
- paid time off (vacation, holidays, sick)
- medical/dental/vision insurance
- 401(k)
- short-term incentive programs
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What This Job Offers
Job Type
Full-time
Career Level
Mid Level
