(Senior / Principal) Scientist, In Vivo Pharmacology

Capable Labs • San Francisco, CA

3d • Onsite

About The Position

We are a vibrant and intensely mission-driven team in San Francisco, comprising members from MIT, Harvard Medical School, Roche, ETH, and Dana-Farber. We value speed and rigor, coupled with excitement, drive, and a strong work ethic. In an early-stage environment, we value people who can bring clarity to open-ended problems, take ownership of the next steps, and follow through with energy. Capable Labs is a place for ambitious, high-integrity people who want to become dramatically better. You will be surrounded by people who care intensely about the work, get close feedback from the people making scientific and company-defining decisions, and have room to own increasingly important problems. We believe excellent work should be met with meaningful reward, ownership, and trust. Responsibility is earned through contribution, not title alone: anyone who demonstrates the judgment, rigor, and follow-through to move important work forward can earn meaningful scope. About the Role You will lead the design, execution, and interpretation of mouse studies that determine whether therapeutic candidates reach the right tissue, engage the target, improve the phenotype, and remain tolerable. You will stay hands-on with in-life work while using PK/PD, efficacy, and safety data to make clear next-study and candidate decisions.

Requirements

• Substantial hands-on experience designing and running mouse studies in biotech, pharma, academia, or a closely related setting.
• Strong translational judgment: you can design studies that test tissue exposure, target engagement, pathway modulation, phenotype, and tolerability.
• Comfort with multi-route dosing, in-life execution, necropsy, tissue and blood collection, sample tracking, and coordination with downstream assays.
• The ability to interpret PK/PD and efficacy data and make disciplined next-study or candidate decisions.
• A fast, rigorous working style with explicit hypotheses, dose rationale, endpoints, controls, and go/no-go criteria.

Nice To Haves

• You do not need prior experience with every route, procedure, or assay listed above.

Responsibilities

• Design, run, and interpret mouse studies evaluating therapeutic candidates across efficacy, pharmacology, and safety.
• Select appropriate dose, route, schedule, tissues, timepoints, endpoints, controls, and go/no-go criteria for each study.
• Perform and guide dosing by routes including IP, IV, SC, PO, intranasal, and other relevant methods based on mechanism and exposure goals.
• Perform or oversee in-life work, blood collection, necropsy, tissue collection, sample tracking, surgeries, and specialized procedures.
• Analyze PK/PD, efficacy, tolerability, biomarker, and tissue data to determine what dose, route, schedule, timepoint, or candidate to test next.
• Design and execute EEG studies where required, including surgery, electrode placement, monitoring, and electrophysiological-data processing.
• Coordinate with downstream molecular, histology, and biomarker workflows and turn each dataset into the next well-controlled experiment.

Benefits

• Generous equity options
• Compensation will depend on the skills, experience, and scope of impact you bring.
• $500+ monthly wellness budget for training, supplements, coaching, recovery, or other tools that help you perform at your best.
• Medical, dental, and vision coverage options, with Capable covering 100% of the base policy.
• HSA, FSA, and 401K plans.
• Healthy dinners with the team are provided daily.
• Visa sponsorship where appropriate, including O-1, H-1B, J-1, TN, and other employment-based pathways.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior
• Education Level: No Education Listed