Scientist II, Complex In Vitro Model

AbbVie•Worcester, MA

2d•$84,500 - $162,000•Onsite

About The Position

AbbVie Immunology is dedicated to discovering breakthrough therapies for inflammatory and auto-immune diseases that can meaningfully improve patients’ lives. The Complex In Vitro Model group is seeking a scientist to support the design, execution, and interpretation of in vitro studies on the characterization of drug candidate molecules and the validation of drug targets.

Requirements

BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism.
Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Responsibilities

Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
Analysis, interpret and clearly communicate quantitative data.
Conduct and organize activities and communicate through oral and written presentations.
Read and apply relevant scientific literature.
Maintenance of accurate and current records of research.