Scientist I, Immunology

Vividion Therapeutics•San Diego, CA

1d•Onsite

About The Position

Vividion is a next generation biotechnology company based in San Diego that is leveraging its proprietary chemical proteomics platform to conduct proteome-wide footprinting of drug-protein interactions with unprecedented breadth and precision. Our technology allows us to screen, identify and optimize novel drugs that selectively bind virtually any protein, including proteins previously considered “undruggable”. Our pipeline and emerging programs reflect a matured and productive platform capable of delivering first in class drugs utilizing novel mechanisms of action (allosteric inhibitors, protein-protein interaction inhibitors, functional activators, degraders etc.) against undruggable targets in the oncology and immunology space. We prize scientific excellence, creativity, team players and we are committed to continued innovation. We have worked hard to create a collaborative and dynamic work culture where your ideas and discoveries are valued and will have an impact. We are growing and there are opportunities for mentorship and career progression. Vividion has been recognized as a Top Workplace by The San Diego Union-Tribune from 2022 to 2025. The successful candidate will have extensive hands-on experience with standard cell biology, molecular and immunological techniques (qPCR, cloning, CRISPR Knock-out/knock-in, western blots, primary cell, immune cell and cell line-based assays, flow cytometry, ELISA, Immunocytochemistry (ICC)). This position will be responsible for executing towards the validation of multiple novel drug targets via a variety of mechanisms, including generating appropriate knockout and knock-in in cells, testing the effects of tool compounds on proteins in cellular and biochemical settings, and the use of Vividion’s proprietary chemical proteomics platform.

Requirements

BS/MS with 10+ years OR PhD with 0-2 years’ experience in molecular biology, cellular biology, immunology or a related field
Expertise in use of various biology techniques including qPCR, CRISPR (Knock-out and knock-in), siRNA or shRNA transfection, Western blot, ELISA, AlphaLISA and MSD assay
Experience in validating and executing cellular assays using primary cells or cell lines to test the activity of compounds
Experience in assay development for compound screening and mechanism of action studies
Proficiency in T cell assays and Immunocytochemistry (ICC) is preferred
Ability and independency to research literature and present ideas/data to support target validation or compound testing

Nice To Haves

Proficiency in T cell assays and Immunocytochemistry (ICC)

Responsibilities

Executing towards the validation of multiple novel drug targets via a variety of mechanisms
Generating appropriate knockout and knock-in in cells
Testing the effects of tool compounds on proteins in cellular and biochemical settings
Utilizing Vividion’s proprietary chemical proteomics platform