Scientist I/II

Camp 4 Ranch•Cambridge, MA

15h•$125,000 - $150,000•Onsite

About The Position

CAMP4 is seeking a highly motivated Scientist to join our Discovery team and contribute to the advancement of CNS programs from target selection through candidate nomination. This is an excellent opportunity for a recent PhD graduate with a strong background in neuroscience or a related discipline who is interested in applying functional neuroscience approaches to drug discovery. A primary responsibility of this role will be to develop and establish functional and phenotypic assays in human iPSC-derived neuronal models to support target validation and characterize the activity of candidate ASOs. The successful candidate will apply approaches such as multielectrode array (MEA), calcium imaging, and high-content imaging to characterize disease-relevant neuronal phenotypes and to evaluate rescue by candidate ASO. The Scientist will work closely with members of the Discovery team as well as cross-functional colleagues in Platform, Chemistry, Preclinical and Data Science. We are looking for a curious, rigorous, and collaborative Scientist who enjoys developing new experimental approaches and translating biological questions into robust cellular assays.

Requirements

PhD in neuroscience, molecular biology, cell biology, or a related discipline with 0-3 years of post-degree experience.
Hands-on experience with neuronal functional or phenotypic assays, with experience in one or more of the following strongly preferred: multielectrode array (MEA), calcium imaging, and high-content imaging.
Strong mammalian cell culture skills; experience with human iPSC-derived neurons, primary neurons, or other neuronal culture systems is highly desirable.
Experience with immunofluorescence, microscopy, and quantitative analysis of cellular phenotypes.
Ability to independently design, execute, troubleshoot, and interpret experiments.
Strong quantitative and analytical skills to generate decision-enabling data packages.
Excellent organizational and communication skills with the ability to work effectively in a fast-paced, collaborative, and multidisciplinary environment.
Scientific curiosity, rigor, attention to detail, and enthusiasm for translating fundamental neuroscience into therapeutic discovery.

Nice To Haves

Experience in one or more of the following strongly preferred: multielectrode array (MEA), calcium imaging, and high-content imaging.
Experience with human iPSC-derived neurons, primary neurons, or other neuronal culture systems is highly desirable.

Responsibilities

Develop, optimize, and implement functional and phenotypic assays in human iPSC-derived neurons, including multielectrode array (MEA), calcium imaging, and high-content imaging.
Establish disease-relevant neuronal phenotypes in patient iPSC-derived neurons and evaluate functional responses to candidate ASOs.
Design and execute experiments supporting target validation though candidate selection across CNS discovery programs.
Develop cellular and biochemical assays to assess target engagement and downstream biological effects of ASOs.
Analyze, interpret, and communicate experimental results to project teams and broader scientific audiences.
Collaborate with cross-functional scientists to integrate functional assay results with molecular, genomic, and pharmacological data to drive project advancement to key go/no-go decisions.
Maintain accurate and detailed experimental records to support regulatory documentation of candidate ASOs.