Scientist, Bioscience Immunology

AstraZeneca•Cambridge, MA

1d•$92,252 - $138,378•Onsite

About The Position

AstraZeneca is seeking a highly motivated, lab-based scientist to characterize immune pathways in health and disease, develop and optimize assays, and generate data that informs program strategy and the discovery and development of novel therapeutics. The position is based in Cambridge, Massachusetts, in AstraZeneca’s laboratories, and focuses predominantly on human in vitro systems, including primary and disease tissue-derived cells. Experience with in vivo science models is a bonus. The scientist will define immunological pathways in autoimmune diseases, develop translational studies, and provide rigorous analysis and actionable conclusions. The role includes contributing to biology and strategy discussions, collaborating with project teams and external partners, and publishing research. Success requires enthusiasm for innovative research, strong communication, and the ability to navigate ambiguity and iterate quickly. The annual base pay range is $92,252 to $138,378. The position offers eligibility for short-term incentive bonuses and equity-based awards for salaried roles. Benefits include qualified retirement programs, paid time off—including vacation, holidays, and leaves—and health, dental, and vision coverage, subject to applicable plan terms.

Requirements

Ph.D. degree with at least 1 year of post-doctoral experience.
Highly organized and self-motivated, with the ability to work independently and collaboratively on high-level research projects.
Proficiency in several of the following: primary cell culture, multi-panel flow cytometry including intracellular and extracellular markers, ELISA, Western blot, and multiplex cytokine readouts such as MSD, AlphaLISA, or Luminex.
Strong written and oral communication skills and the ability to critically analyze datasets.
Ability to record protocols and experiments promptly and maintain an excellent laboratory notebook.
Demonstrated ability to run collaborative efforts and use external resources to find effective solutions to drug discovery problems.

Nice To Haves

Expertise in immunology drug discovery projects or a closely related field of biology is preferred.
Knowledge and experience with in vivo science models.
Biotechnology or pharmaceutical experience is preferred but not essential.

Responsibilities

Define and interrogate novel immunological pathways in autoimmune diseases to support target validation and therapeutic hypotheses for drug projects.
Design, execute, and refine studies using primary and disease tissue-derived cells to generate translational data for program decisions.
Build, optimize, and qualify cellular, molecular, and protein assays, establishing standards and controls for reproducibility and decision-grade data.
Apply rigorous experimental design and statistical thinking to analyze complex datasets and communicate actionable conclusions.
Collaborate with project teams and external partners, align on goals, share insights, and bring in external science and technologies when advantageous.
Lead aspects of the biology, contribute to strategy discussions, and publish high-quality research in reputable journals.
Adapt to ambiguity, learn from setbacks, and use inventive approaches to keep programs moving.