Scientist, Early Discovery & Immunology
About The Position
BeOne Medicines is seeking a highly motivated Scientist to join its early discovery group at BeOne Institute in San Carlos, California. The Institute pursues novel therapeutic ideas through rapid innovation, aligns research with BeOne’s R&D priorities, and translates insights into impactful pipeline programs. The role combines hands-on laboratory execution with a drug-development mindset, focusing on cell engineering, assays, and screening workflows that advance biological concepts toward scalable therapeutic assets. The Scientist will work across project initiatives, design and execute experimental strategies to modulate the immune system, and collaborate cross-functionally. The position must be performed onsite in San Carlos, California; travel is not required. There are no supervisory responsibilities.
Requirements
- Ph.D., M.S., or B.S. degree in Immunology, Cell Biology, Bioengineering, Molecular Biology, or a related scientific field.
- At least 4 years of relevant industry or academic experience with an M.S., or at least 6 years with a B.S.
- Demonstrated hands-on expertise in at least two of the following: primary T-cell biology; iPSC culture and differentiation; gene editing modalities such as CRISPR, CRISPRa/i, or base editing; lentiviral or non-viral cell engineering; mRNA design, formulation, or delivery; functional screening approaches.
- Working knowledge of standard molecular biology techniques such as cloning, qPCR, and plasmid assembly.
- Hands-on experience with multi-color flow cytometry, including panel design, and primary immune-cell functional assays.
- Technical proficiency with cell sorting and isolation techniques.
- Ability to independently design and execute experiments, rigorously analyze data, and clearly present results.
- Ability to work onsite in San Carlos, California.
Nice To Haves
- Prior experience in drug discovery or translational biology environments.
- Hands-on experience processing and analyzing in vivo tissue or blood samples.
- Experience with 3D cell culture systems, such as organoids, tumor spheroids, or microfluidic models, to evaluate immune-cell activity.
- Basic programming skills in R or Python for biological data processing and analysis.
Responsibilities
- Independently design, execute, and analyze experimental workflows for early discovery projects, generating high-quality data packages.
- Perform molecular biology techniques supporting construct design, library assembly, and vector or mRNA preparation.
- Isolate, culture, and engineer primary human immune cells, including primary T cells, and/or manage iPSC culture and differentiation workflows.
- Perform multi-color flow cytometry, cell sorting (FACS), magnetic isolation, and quantitative immune-cell functional assays such as activation, cytotoxicity, and cytokine profiling.
- Build, optimize, and run pooled or arrayed functional screening approaches to evaluate novel targets and therapeutic constructs.
- Troubleshoot assays, analyze biological data, and provide experimental insights to guide project strategy and decision-making.
- Present experimental results and data packages to cross-functional project teams and discovery leadership.
- Contribute to laboratory operational workflows, technical protocols, and material management at the San Carlos site.
Benefits
- Annual bonus plan eligibility for non-commercial roles; commercial roles are eligible for an incentive compensation plan.
- Opportunity for all employees to receive discretionary equity awards and voluntarily participate in the Employee Stock Purchase Plan.
- Medical insurance.
- Dental insurance.
- Vision insurance.
- 401(k).
- FSA/HSA.
- Life insurance.
- Paid time off.
- Wellness benefits.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
