Associate Principal Scientist, Immunology Discovery
About The Position
The Discovery Immunology organization is developing therapies for inflammatory and autoimmune diseases across Gastroenterology, Rheumatology, and Dermatology. The Associate Principal Scientist will join the Immunology Discovery team in San Diego and serve as Project Lead on early-to-late-stage immunology programs. The role will drive strategies and technologies for target validation, differentiation, risk reduction, and development of next-generation therapeutic modalities. The successful candidate will lead large cross-functional teams, define and execute discovery strategies for multiple programs, and support advancement of immunology and inflammation therapeutics from early discovery to clinical candidates. The role also represents project teams at senior governance meetings to inform portfolio and investment decisions. This is a regular position with a first-shift schedule, 10% travel, and domestic or international relocation available. Visa sponsorship is offered.
Requirements
- Ph.D. in immunology, cell biology, or a related biomedical science, with 5+ years of experience and relevant drug discovery experience.
- Demonstrated experience leading early-to-late-stage discovery programs and cross-functional teams in a matrixed environment.
- Strong immunology background and extensive knowledge of immune-mediated diseases in Gastroenterology, Rheumatology, or Dermatology, and related preclinical models.
- Broad experience with cell biology techniques, including culture of cell lines, immune cells, and other primary cells; in vitro and ex vivo cell-based assays; and multicolor flow cytometry.
- Experience with immunoassay platforms such as ELISA and molecular biology techniques such as RT-PCR.
- Proficiency in data analysis using Excel, GraphPad Prism, and FlowJo.
- Ability to work independently and effectively in cross-functional, matrixed teams.
- Strong problem-solving and critical-thinking skills.
- Ability to lead by influencing and mentoring others.
- Ability to communicate data and program strategies effectively to broad audiences.
Nice To Haves
- Experience leading cross-functional biologics or chemistry discovery programs in Gastroenterology, Dermatology, and/or Rheumatology, especially autoimmune or immune-mediated disorders, in large and small pharmaceutical contexts.
- Experience in translational research and biomarker discovery.
- Prior experience working with multiple therapeutic modalities, such as small molecules, peptides, and biologics.
Responsibilities
- Define and drive drug discovery immunology project and program strategies, collaborating with Discovery Immunology and other functional areas to achieve organizational objectives.
- Lead multiple cross-functional teams advancing therapeutic candidates from early discovery to clinic, ensuring timely completion of milestones.
- Present program recommendations, key milestones, and strategic decisions to senior-level governance committees.
- Independently design, execute, and interpret complex in vitro and ex vivo studies, while leading and overseeing others’ experiments.
- Identify, validate, and implement innovative approaches and technologies to increase efficiency and productivity and drive program progression.
- Share expertise and mentor less experienced scientists, supporting scientific rigor, collaboration, and continuous learning.
- Integrate and interpret complex data and communicate science and strategy to stakeholders and management.
Benefits
- Medical, dental, and vision healthcare and other insurance benefits for employees and family.
- Retirement benefits, including 401(k).
- Paid holidays, vacation, and compassionate and sick days.
- Eligible for annual bonus and long-term incentive, if applicable.
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
