Principal Scientist, Biology (Immunology)
About The Position
C4 Therapeutics is seeking an innovative Principal Scientist, Biology (Immunology) to develop medicines for autoimmune and inflammatory diseases using its targeted protein degradation (TPD) platform. This highly visible, laboratory-based role leads mechanism-driven programs from target identification through IND-enabling studies. The scientist applies deep expertise in immunology and human disease biology, together with hands-on work in primary human immune cell systems, to understand how degraders reshape immune pathways, translate mechanistic insights into program advances, and build mechanistic and translational evidence to advance therapies. The position offers the opportunity to shape a pipeline and work in a collaborative environment with strong leadership, defined growth opportunities, and exposure to state-of-the-art science.
Requirements
- Ph.D. in Immunology or a related field.
- Substantial research experience and a minimum of ten years in biotechnology or pharmaceutical drug discovery.
- Proven success leading autoimmune and/or inflammatory programs from target validation through candidate selection and preclinical development.
- Deep hands-on experience developing primary immune cell assays and mechanism-of-action studies across cytokine, innate, T-cell, myeloid, and inflammatory signaling pathways to study intracellular signaling, using methods such as flow cytometry, MSD, ELISA, differentiation, and polarization activities.
- Expertise in immune cell and autoimmune disease biology, cellular and molecular assay development, translational pharmacology, biomarker strategy, and immune-targeted therapeutics.
- Demonstrated immunology expertise with a strong record of publications, patents, development candidates, or pipeline contributions.
- Proven matrixed leadership experience, including program leadership, scientific mentorship, and management of CROs and/or outsourced vendors.
Nice To Haves
- Experience with targeted protein degradation and/or disease pathophysiology.
- Experience filing an IND and/or in clinical development activities.
- Experience working with external collaborations with other life science companies and/or academic institutions.
Responsibilities
- Independently design, execute, optimize, and troubleshoot experiments, including complex primary human immune cell assays using PBMCs, purified immune cell subsets, whole blood, and patient-derived samples, to elucidate degrader mechanisms of action, establish translational biomarkers, and support candidate selection.
- Use hands-on pharmacology studies to define links among target degradation, pathway modulation, and functional immune outcomes.
- Apply immune signaling and activation expertise to select relevant systems, stimuli, and mechanistic readouts.
- Lead immunology discovery programs from target identification through candidate selection, partnering across functions to deliver company goals.
- Set program strategy, milestones, and experiments that build translational data packages and support development.
- Integrate biology, pharmacology, and chemistry data to guide program and portfolio decisions.
- Identify and validate novel autoimmune and inflammatory disease targets and pathways.
- Analyze and clearly present data to project teams and broader stakeholders.
- Build and manage strategic academic and industry collaborations.
- Mentor scientists and foster scientific rigor, innovation, and collaboration.
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What This Job Offers
Job Type
Full-time
Career Level
Principal
Education Level
Ph.D. or professional degree
