Associate Principal Scientist, Immunology Discovery
About The Position
The Discovery Immunology organization is developing therapies for inflammatory and autoimmune diseases across Gastroenterology, Rheumatology, and Dermatology. The Associate Principal Scientist will join the Immunology Discovery team in San Diego and serve as Project Lead for early-to-late-stage immunology programs. The role drives the design and implementation of strategies and technologies for target validation, differentiation, risk reduction, and development of next-generation modalities. The successful candidate will define and execute discovery strategy across multiple programs, lead large cross-functional teams, and advance immunology and inflammation therapeutics from early discovery to clinical candidates. The role also represents project teams at senior governance meetings to support portfolio and investment decisions.
Requirements
- Ph.D. in immunology, cell biology, or a related biomedical science, with 5 or more years of experience and relevant drug discovery experience.
- Demonstrated experience leading early-to-late-stage discovery programs and cross-functional teams in a matrixed environment.
- Strong immunology background, including extensive knowledge of immune-mediated diseases in Gastroenterology, Rheumatology, or Dermatology and related preclinical models.
- Broad experience with cell biology techniques, including culture of cell lines, immune cells, and other primary cells; in vitro and ex vivo cell-based assays; and multicolor flow cytometry.
- Experience with immunoassay platforms, such as ELISA, and molecular biology techniques, such as RT-PCR.
- Proficiency in data analysis using Excel, GraphPad Prism, and FlowJo.
- Ability to work independently and effectively within cross-functional and matrixed teams.
- Strong problem-solving and critical-thinking skills.
- Ability to lead by influencing and mentoring others.
- Ability to communicate data and program strategies effectively to broad audiences.
Nice To Haves
- Experience leading cross-functional biologics or chemistry discovery programs in Gastroenterology, Dermatology, and/or Rheumatology, especially in autoimmune or immune-mediated disorders, including in both large- and small-pharma contexts.
- Experience in translational research and biomarker discovery.
- Prior experience working with multiple therapeutic modalities, such as small molecules, peptides, and biologics.
Responsibilities
- Define and drive drug discovery immunology project and program strategies, collaborating across Discovery Immunology and other functional areas to achieve organizational objectives.
- Lead multiple cross-functional teams advancing therapeutic candidates from early discovery to the clinic, ensuring timely completion of milestones.
- Present program recommendations, key milestones, and strategic decisions to senior-level governance committees.
- Independently design, execute, and interpret complex in vitro and ex vivo studies aligned with program goals, while leading and overseeing others’ experiments.
- Identify, validate, and implement innovative approaches and technologies to increase efficiency and productivity and drive program progression.
- Share expertise and mentor less experienced scientists, fostering scientific rigor, collaboration, and continuous learning.
- Integrate and interpret complex data and communicate science and strategy to stakeholders and management.
Benefits
- Medical, dental, and vision healthcare benefits
- Other insurance benefits for employees and their families
- Retirement benefits, including 401(k)
- Paid holidays
- Vacation
- Compassionate and sick days
- Eligible for annual bonus and long-term incentive, if applicable
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What This Job Offers
Job Type
Full-time
Career Level
Senior
Education Level
Ph.D. or professional degree
