Scientist, Analytical and Biological Mass Spectrometry (ABMS)

Regeneron Pharmaceuticals • Tarrytown, GA

6d • $93,900 - $153,300 • Onsite

About The Position

Regeneron is seeking a highly motivated Scientist to join its Analytical and Biological Mass Spectrometry (ABMS) team and support R&D programs. The role is based in a collaborative mass spectrometry laboratory focused on the biochemical characterization of emerging therapeutic modalities and monoclonal antibodies across all stages of development. The position offers hands-on project work in a fast-growing, science-driven organization developing medicines for people with serious diseases.

The Scientist develops and optimizes primarily LC-MS-based analytical methods, analyzes and interprets LC-MS data, and supports R&D activities and regulatory submissions. The role independently performs sample preparation and LC-MS experiments, documents work in electronic laboratory notebooks, presents data, and prepares technical reports, SOPs, and regulatory documents. It also calls for clear scientific communication, ownership of experimental work, transparent recordkeeping, and ongoing learning and collaboration.

This is a full-time position based at Regeneron’s Tarrytown headquarters and requires at least four days per week onsite.

Requirements

• BS or MS (or higher) in chemistry, biochemistry, analytical chemistry, pharmaceutical sciences, metabolism, or a related field.
• 6–8+ years of industrial or academic experience in analytical characterization of small molecules, antibodies, protein therapeutics, AAVs, metabolites, lipids, or other therapeutic modalities.
• Knowledge of and hands-on experience with LC-MS-based sample preparation for cells, tissues, biological matrices, and drug substances.

Nice To Haves

• Strong knowledge of metabolism and hands-on experience in metabolomics or lipidomics.
• Experience with metabolic flux analysis, isotope tracing, or related quantitative approaches.
• Knowledge of pharmaceutical formulation and process development.
• Knowledge of and experience in AAV virology, siRNA, and structural biology.
• Experience with automated liquid-handling systems such as Biomek, Bravo, KingFisher, Tecan, or similar platforms.
• Experience with specialized LC-MS-based techniques such as hydrogen-deuterium exchange mass spectrometry (HDX-MS), ion mobility spectrometry-mass spectrometry (IMS-MS), and quantitative proteomics.
• Experience with experimental design and data analysis, including design of experiments (DoE), molecular modeling, graphing, statistical analysis, or quantitative pathway and flux analysis software.

Responsibilities

• Develop and optimize primarily LC-MS-based analytical methods for diverse R&D programs, applying sound scientific judgment and understanding of the methods and experiments performed.
• Analyze and interpret LC-MS data using appropriate software and bioinformatics tools to characterize quality attributes of therapeutic proteins and emerging modalities.
• Support R&D activities and regulatory submissions while expanding organizational knowledge of antibody therapeutics and other emerging modalities.
• Independently perform sample preparation and LC-MS-based experiments according to SOPs, and document experiments, results, and conclusions in electronic laboratory notebook (ELN) entries.
• Present data at group and project meetings and prepare technical reports, SOPs, and regulatory submission documents.
• Summarize results clearly and concisely using graphs, figures, and tables for presentations, peer-reviewed publications, and regulatory documents.
• Communicate with integrity, honesty, and respect in written and verbal interactions; contribute to scientific discussions and raise questions or concerns when appropriate.
• Take ownership of experimental work, discuss unexpected results, identify root causes, make timely corrections, and maintain accurate and transparent records.
• Learn new technologies and scientific concepts through project participation, collaboration, and constructive feedback, while contributing to a team environment.

Benefits

• Competitive and comprehensive total rewards package, which may include annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, medical, dental, vision, life and disability insurance, paid time off, and family support benefits, depending on country and role.

What This Job Offers

• Job Type: Full-time
• Career Level: Senior