About The Position

This academic-credit internship in the Guzman Lab within the Department of Neurology provides students and trainees with supervised exposure to translational human neuroscience research and experimental neuropathology. The Neuropathology Core Laboratory and Alzheimer's Disease Brain Bank integrate human brain banking and neuropathologic characterization with histology, immunohistochemistry, spatial transcriptomics, digital pathology, quantitative image analysis, and molecular data analysis. Research areas include Alzheimer's disease and related neurodegenerative disorders, ALS, tauopathies, epilepsy, neuro-inflammatory disease, and other neurologic conditions. The internship is intended for students interested in medicine, neuroscience, pathology, or biomedical research. Under supervision, the intern will learn about brain bank workflows, neuroanatomy, neuropathologic assessment, histology and immunohistochemistry, digital pathology, quantitative image analysis, spatial transcriptomics, and research data analysis. The educational objective is to develop practical research skills, scientific reasoning, and an understanding of how human tissue research can inform biomarkers, disease mechanisms, and future therapeutic investigation. The internship typically lasts no more than twelve months.

Requirements

  • Must be 18 years of age or older.
  • Must have a high school diploma or GED.
  • Must reside in the greater Los Angeles area or surrounding cities while conducting activities related to the intern or visitor appointment.
  • Students participating for academic credit must receive academic credit for the duration of the internship.

Responsibilities

  • Complete orientation and foundational training in research compliance, laboratory safety, human brain anatomy, brain banking, tissue preservation, and principles of neuropathologic diagnosis and translational research.
  • Gain supervised exposure to approved brain bank and neuropathology workflows, including neuroanatomic sampling, tissue processing, histology, immunohistochemistry, digital slide review, and organization of de-identified research material.
  • Participate in a supervised experimental neuropathology project; activities may include immunohistochemistry, quantitative image analysis, literature review, data organization, and introduction to spatial transcriptomics datasets.
  • Develop image and data analysis skills and learn to integrate neuropathology with spatial transcriptomics and other molecular findings.
  • Participate in research discussions, interpretation of results, and development of research questions.
  • Complete a mentored research or neuropathology case-based project and prepare a scientific presentation describing the question, methods, results, and significance.
  • Contribute to abstracts, posters, or manuscripts when appropriate to the trainee's contribution.
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