Research Fellow - Cancer Biology

Mass General Brigham•Boston, MA

4d•$70,000 - $71,750•Onsite

About The Position

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Will conduct independent and collaborative research, contributing to the advancement of knowledge and the development of innovative solutions. The fellow will work under the supervision of the Principal Investigator and collaborate with a team of researchers.

Requirements

Doctorate Related Field of Study required
Previous Research experience 3-5 years required
Demonstrated experience in research techniques, methods, or research areas relevant to the project.
Proficient analytical skills, proficiency in statistical software, and excellent written and verbal communication skills.
Ability to work independently as well as collaboratively within a team.
Good interpersonal and communication skills.
Strong proficiency in following experimental protocols with precision, maintaining accurate records, and working with biological samples is essential.

Nice To Haves

PhD in molecular biology, Biochemistry, biophysics, immunology, or related field strongly preferred.
Demonstrated hands-on experience with animal models and/or a strong background in cell culture and molecular biology techniques, including tissue handling, mammalian cell culture, and standard biochemical assays.
Prior experience with xenograft and orthotopic murine tumor models, cancer biology research, as well as familiarity with molecular biology techniques such as Western blotting, nucleic acid extraction, single-cell RNA sequencing, spatial biology, flow cytometry, immunofluorescence, and immunohistochemistry.
Exposure to biomedical imaging, quantitative assays, or interdisciplinary research environments integrating biology and technology is desirable.

Responsibilities

Design, plan, and execute research experiments or projects in alignment with departmental goals.
Gather, analyze, and interpret data using appropriate statistical methods and tools.
Conduct comprehensive literature reviews to inform research direction and methodologies.
Prepare and publish research findings in peer-reviewed journals and present at conferences and seminars.
Work collaboratively with faculty, students, and other researchers, contributing to a positive research environment.
Mentor graduate and undergraduate students, providing guidance on research methodologies and techniques.
Assist in the preparation of grant proposals and funding applications to support ongoing research.
Prepare periodic reports and documents summarizing research progress and outcomes.
Establishing, maintaining, and monitoring orthotopic and xenograft murine tumor models
Subcutaneous, IP, and IV injections
Handling and processing of mouse tissues following in vivo experiments
Supporting ex vivo tissue preparation and analysis, including sample preservation for downstream assays
Maintaining routine 2D and 3D mammalian cell culture
Establishing and expanding primary cell lines from tumor or tissue specimens
Performing cell-based assays to evaluate biological responses to therapeutic or imaging agents
Supporting experimental design and execution of mechanistic studies in vitro
Tissue processing for downstream molecular analyses
Extraction of DNA, RNA, and proteins from tissue and cell samples
Western blotting, immunodetection, and related protein analysis techniques
Flow cytometry and sample preparation for immune and tumor cell profiling
Supporting downstream data interpretation in collaboration with investigators