Research Associate/Senior Research Associate, Oligonucleotide Chemistry

Korro Bio•Cambridge, MA

7d•Onsite

About The Position

Korro Bio is seeking a motivated, detail-oriented Research Associate to join its Oligonucleotide Chemistry team. The role synthesizes, purifies, and characterizes chemically modified oligonucleotides and conjugates using automated platforms, supplying materials for screening across Korro’s discovery programs. It is a hands-on, lab-based position for someone with practical oligonucleotide synthesis experience who takes ownership of instrument operation and maintenance, keeps meticulous records, and communicates results clearly with the team and cross-functionally. The position reports to Scientist II and is based on-site in Cambridge, Massachusetts. The role offers a base salary range of $70,000–$110,000, with final salary determined by the level at which the role is filled and by job-related factors. The stated range does not include annual bonus or equity. Korro describes its culture as collaborative and mission-driven, with values including Rewrite the Future, On the Cutting Edge, Better Together, Dynamically Different, Kindness, and Integrity.

Requirements

BS or MS in Chemistry, Biochemistry, Biotechnology, or a related field, with at least 1 year of experience.
Hands-on experience in the synthesis, purification, and analysis of oligonucleotides.
Strong laboratory skills and experience handling, troubleshooting, and routinely maintaining lab equipment, including automated synthesis platforms, HPLC, and LC-MS.
Flexibility and self-motivation in a fast-paced work environment.
Excellent organizational skills and ability to prioritize appropriately and meet deadlines.
Excellent interpersonal, communication, and presentation skills.
Detail-oriented with excellent problem-solving abilities.

Nice To Haves

Experience with high-throughput synthesizers such as Mermade 192.

Responsibilities

Execute solid-phase synthesis, purification, and downstream processing of chemically modified oligonucleotides and oligonucleotide conjugates at different scales using automated oligonucleotide synthesis platforms.
Operate, maintain, and troubleshoot equipment for oligonucleotide synthesis, including Mermade 12 and Mermade 192, as well as purification, desalting, and lyophilization equipment.
Cross-train with other synthesis scales and instrumentation.
Maintain inventory of chemicals and amidites for oligonucleotide synthesis.
Perform in-process and final analytics of oligonucleotide samples as needed.
Track, analyze, organize, and present data to the team and cross-functionally.
Maintain a well-documented electronic laboratory notebook.
Participate in training activities and provide training to others as needed.
Author and review SOPs and technical reports.